a Department of Physiology and Pharmacology, School of Medicine , North Khorasan University of Medical Sciences , Bojnurd , Iran.
b Department of Medical and Surgical Sciences , University of Bologna , Via Albertoni 15, Bologna , Italy.
Crit Rev Food Sci Nutr. 2019;59(1):89-101. doi: 10.1080/10408398.2017.1358139. Epub 2017 Sep 6.
Cytokines are small secreted proteins released by different types of cells with specific effects on cellular signaling and communication via binding to their receptors on the cell surface. IL-10 is known to be a pleiotropic and potent anti-inflammatory and immunosuppressive cytokine that is produced by both innate and adaptive immunity cells including dendritic cells, macrophages, mast cells, natural killer cells, eosinophils, neutrophils, B cells, CD8 T cells, and T1, T2, and T17 and regulatory T cells. Both direct and indirect activation of the stress axis promotes IL-10 secretion. IL-10 deregulation plays a role in the development of a large number of inflammatory diseases such as neuropathic pain, Parkinson's disease, Alzheimer's disease, osteoarthritis, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, type 1 diabetes, inflammatory bowel disease, and allergy. Curcumin is a natural anti-inflammatory compound able to induce the expression and production of IL-10 and enhancing its action on a large number of tissues. In vitro and in pre-clinical models curcumin is able to modulate the disease pathophysiology of conditions such as pain and neurodegenerative diseases, bowel inflammation, and allergy, but also of infections and cancer through its effect on IL-10 secretion. In humans, at least one part of the positive effects of curcumin on health could be related to its ability to enhance IL-10 -mediated effects.
细胞因子是由不同类型的细胞分泌的小分泌蛋白，通过与细胞表面的受体结合，对细胞信号转导和通讯具有特定的影响。IL-10 是一种多效性的、强效的抗炎和免疫抑制细胞因子，由先天和适应性免疫细胞产生，包括树突状细胞、巨噬细胞、肥大细胞、自然杀伤细胞、嗜酸性粒细胞、中性粒细胞、B 细胞、CD8 T 细胞、T1、T2 和 T17 以及调节性 T 细胞。应激轴的直接和间接激活都促进了 IL-10 的分泌。IL-10 的失调在许多炎症性疾病的发展中起着重要作用，如神经病理性疼痛、帕金森病、阿尔茨海默病、骨关节炎、类风湿关节炎、银屑病、系统性红斑狼疮、1 型糖尿病、炎症性肠病和过敏。姜黄素是一种天然的抗炎化合物，能够诱导 IL-10 的表达和产生，并增强其在大量组织中的作用。在体外和临床前模型中，姜黄素能够调节疼痛和神经退行性疾病、肠道炎症和过敏等疾病的病理生理学，还能够通过影响 IL-10 的分泌来调节感染和癌症。在人类中，姜黄素对健康的至少一部分积极影响可能与其增强 IL-10 介导的作用的能力有关。
