Student Research Committee, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Adv Exp Med Biol. 2021;1291:151-164. doi: 10.1007/978-3-030-56153-6_9.
Plant extracts have been used to treat a wide range of human diseases. Curcumin, a bioactive polyphenol derived from Curcuma longa L., exhibits therapeutic effects against diabetes while only negligible adverse effects have been observed. Antioxidant and anti-inflammatory properties of curcumin are the main and well-recognized pharmacological effects that might explain its antidiabetic effects. Additionally, curcumin may regulate novel signaling molecules and enzymes involved in the pathophysiology of diabetes, including glucagon-like peptide-1, dipeptidyl peptidase-4, glucose transporters, alpha-glycosidase, alpha-amylase, and peroxisome proliferator-activated receptor gamma (PPARγ). Recent findings from in vitro and in vivo studies on novel signaling pathways involved in the potential beneficial effects of curcumin for the treatment of diabetes are discussed in this review.
植物提取物被用于治疗多种人类疾病。姜黄素是一种从姜黄中提取的生物活性多酚，对糖尿病具有治疗作用，而仅观察到可忽略不计的不良反应。姜黄素的抗氧化和抗炎特性是其主要的、公认的药理学作用，这可能解释了其抗糖尿病作用。此外，姜黄素可能调节新型信号分子和参与糖尿病病理生理学的酶，包括胰高血糖素样肽-1、二肽基肽酶-4、葡萄糖转运体、α-糖苷酶、α-淀粉酶和过氧化物酶体增殖物激活受体γ（PPARγ）。本文综述了关于姜黄素在治疗糖尿病方面的潜在有益作用的新型信号通路的体外和体内研究的最新发现。
