Department of Pharmacy, G. d'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy.
Department of Pharmacy, G. d'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy.
Biomed Pharmacother. 2021 Oct;142:111963. doi: 10.1016/j.biopha.2021.111963. Epub 2021 Jul 28.
Nowadays cardiovascular diseases (CVDs) are the major causes for the reduction of the quality of life. The endocannabinoid system is an attractive therapeutic target for the treatment of cardiovascular disorders due to its involvement in vasomotor control, cardiac contractility, blood pressure and vascular inflammation. Alteration in cannabinoid signalling can be often related to cardiotoxicity, circulatory shock, hypertension, and atherosclerosis. Plants have been the major sources of medicines until modern eras in which researchers are experiencing a rediscovery of natural compounds as novel therapeutics. One of the most versatile plant is Cannabis sativa L., containing phytocannabinoids that may play a role in the treatment of CVDs. The aim of this review is to collect and investigate several less studied plants rich in cannabinoid-like active compounds able to interact with cannabinoid system; these plants may play a pivotal role in the treatment of disorders related to the cardiovascular system.
如今，心血管疾病（CVDs）是降低生活质量的主要原因。内源性大麻素系统因其参与血管舒缩控制、心肌收缩力、血压和血管炎症而成为治疗心血管疾病的一个有吸引力的治疗靶点。大麻素信号的改变通常与心脏毒性、循环休克、高血压和动脉粥样硬化有关。在现代之前，植物一直是药物的主要来源，在此期间，研究人员正在重新发现天然化合物作为新型治疗药物。最具多功能性的植物之一是 Cannabis sativa L.，它含有植物大麻素，可能在治疗 CVDs 中发挥作用。本综述的目的是收集和研究几种富含类大麻素活性化合物的研究较少的植物，这些植物能够与大麻素系统相互作用；这些植物可能在治疗与心血管系统相关的疾病方面发挥关键作用。
