Laboratory of Biomedical Genomics and Oncogenetics, Faculty of Sciences and Technology, Abdelmalek Essaadi University, Tangier, Morocco.
Pasteur Institute of Tangier, Morocco.
Microvasc Res. 2020 Sep;131:104023. doi: 10.1016/j.mvr.2020.104023. Epub 2020 May 30.
Obesity is a chronic disease responsible for a high morbidity and mortality rate, with an increasing worldwide prevalence. Obesity is associated with immune responses characterized by chronic systemic inflammation. This article focuses on the mechanisms that explain the proposed link between obesity-associated diseases and inflammation. Also, it describes the role of inflammatory molecules in obesity-associated metabolic abnormalities.
More than 200 articles were selected and consulted by an online English search using various electronic search databases. Predefined key-words for the pathogenesis of obesity-induced inflammation and associated diseases, as well as the role of various inflammatory molecules, were used.
We have summarized the data of the articles consulted in this research and we have found that obesity is associated with a low-grade inflammation resulting from the change of adipose tissue (AT). The AT produces a variety of inflammatory molecules called adipocytokines that are involved in the onset of systemic low-grade inflammation which is the link between obesity and associated-chronic abnormalities; such as insulin resistance, metabolic syndrome, cardiovascular disease (CVD), hypertension, diabetes, and some cancers. Also, we have searched all the inflammatory molecules involved in this pathogenesis and we have briefly described the role of 16 of them which are the most related to obesity-associated inflammation. The results have shown that there are inflammatory molecules that have a positive relationship with the pathogenesis of obesity-related diseases and others have a negative relationship with this pathogenesis.
Inflammation plays a crucial role in the development of various metabolic-abnormalities related to obesity. In this regard, the management of obesity may help reduce the risk of cardiovascular disease and other metabolic complications by inhibiting inflammatory mechanisms.
肥胖是一种慢性病，导致高发病率和死亡率，且在全球范围内的患病率不断上升。肥胖与以慢性系统性炎症为特征的免疫反应有关。本文重点介绍了解释肥胖相关疾病与炎症之间拟议联系的机制。此外，还描述了炎症分子在肥胖相关代谢异常中的作用。
通过在线英语搜索，使用各种电子搜索数据库，选择并查阅了 200 多篇文章。使用了与肥胖引起的炎症和相关疾病的发病机制以及各种炎症分子的作用相关的预定义关键词。
我们总结了本研究中查阅的文章的数据，发现肥胖与脂肪组织 (AT) 变化引起的低度炎症有关。AT 产生多种称为脂肪细胞因子的炎症分子，这些分子参与全身性低度炎症的发生，这是肥胖与相关慢性异常之间的联系；如胰岛素抵抗、代谢综合征、心血管疾病 (CVD)、高血压、糖尿病和一些癌症。此外，我们还搜索了所有涉及这种发病机制的炎症分子，并简要描述了其中 16 种与肥胖相关炎症最相关的作用。结果表明，有些炎症分子与肥胖相关疾病的发病机制呈正相关，而另一些则呈负相关。
炎症在与肥胖相关的各种代谢异常的发展中起着至关重要的作用。在这方面，通过抑制炎症机制，肥胖的管理可能有助于降低心血管疾病和其他代谢并发症的风险。
