Singapore-MIT Alliance for Research and Technology, Antimicrobial Drug Resistance Interdisciplinary Research Group, Singapore; Singapore Centre for Environmental Life Science Engineering, Nanyang Technological University, Singapore.
Singapore-MIT Alliance for Research and Technology, Antimicrobial Drug Resistance Interdisciplinary Research Group, Singapore; Singapore Centre for Environmental Life Science Engineering, Nanyang Technological University, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore.
Curr Opin Microbiol. 2021 Oct;63:117-125. doi: 10.1016/j.mib.2021.07.001. Epub 2021 Jul 29.
Biofilm formation is a multifactorial process and often a multi-species endeavour that involves complex signalling networks, chemical gradients, bacterial adhesion, and production or acquisition of matrix components. Antibiotics remain the main choice when treating bacterial biofilm-associated infections despite their intrinsic tolerance to antimicrobials, and propensity for acquisition and rapid dissemination of antimicrobial resistance within the biofilm. Eliminating hard to treat biofilm-associated infections that are antibiotic resistant will demand a holistic and multi-faceted approach, targeting multiple stages of biofilm formation, many of which are already in development. This mini review will highlight the current approaches that are employed to treat bacterial biofilm infections and discuss new approaches in development that have promise to reach clinical practice.
生物膜的形成是一个多因素的过程，通常是一个多物种的努力，涉及复杂的信号网络、化学梯度、细菌黏附以及基质成分的产生或获取。尽管抗生素具有固有耐药性，并且容易在生物膜内获得和快速传播抗生素耐药性，但在治疗与细菌生物膜相关的感染时，抗生素仍然是主要选择。要消除对抗生素耐药的难以治疗的生物膜相关感染，需要采用整体的、多方面的方法，针对生物膜形成的多个阶段，其中许多方法已经在开发中。这篇小型综述将重点介绍目前用于治疗细菌生物膜感染的方法，并讨论正在开发的有希望应用于临床实践的新方法。
