Bakirhan Nurgul K, Kaya S Irem, Jabbarov Rasim, Gahramanova Gulnaz, Abdullayeva Sevda, Dedeoglu Aylin, Ozkan Cansel Kose, Savaser Ayhan, Ozkan Yalcin, Ozkan Sibel A
Gulhane Faculty of Pharmacy, Department of Analytical Chemistry, University of Health Sciences, Ankara, Turkey.
Faculty of Pharmacy, Department of Analytical Chemistry, Ankara University, Ankara, Turkey.
Crit Rev Anal Chem. 2023;53(2):374-383. doi: 10.1080/10408347.2021.1958296. Epub 2021 Aug 1.
Nowadays, carbon nanotubes (CNTs) due to their inorganic conducting, semiconducting, and organic π-π stacking properties are becoming innovative materials. CNTs have an adjustable size, large surface area, and other significant chemical properties. Due to their excellent electrical, optical, and mechanical properties, CNTs play an important role in various application fields. In the past decade, many unique intrinsic physical and chemical properties have been intensively explored for pharmaceutical, biological, and biomedical applications. The functionalization of CNTs results in a remarkably reduced cytotoxicity and at the same time increased biocompatibility. The toxicity studies reveal that highly water-soluble and serum stable nanotubes are biocompatible, nontoxic, and potentially useful for biomedical applications. Ultrasensitive drug determination from its dosage form and/or biological samples with carbon nanotubes can be realized after surface modification. The main purpose of this review is to present recent achievements on CNTs which are investigated in electrochemical and chromatographically sensing technologies.
如今，碳纳米管（CNTs）因其无机导电、半导体以及有机π-π堆积特性，正成为创新材料。碳纳米管具有可调节的尺寸、大表面积以及其他显著的化学性质。由于其优异的电学、光学和机械性能，碳纳米管在各种应用领域发挥着重要作用。在过去十年中，人们对碳纳米管许多独特的固有物理和化学性质进行了深入探索，以用于制药、生物和生物医学应用。碳纳米管的功能化导致细胞毒性显著降低，同时生物相容性增加。毒性研究表明，高度水溶性和血清稳定的纳米管具有生物相容性、无毒，并且在生物医学应用中具有潜在用途。表面修饰后，利用碳纳米管可实现从其剂型和/或生物样品中进行超灵敏药物测定。本综述的主要目的是介绍碳纳米管在电化学和色谱传感技术方面的最新研究成果。
