Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Sunshine Southern Avenue, Fang-Shan District, Beijing 102488, China.
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian-Nong-Tan Street, Xi-Cheng District, Beijing 100050, China.
Phytomedicine. 2021 Sep;90:153669. doi: 10.1016/j.phymed.2021.153669. Epub 2021 Jul 22.
Depression, as a prevalent and debilitating psychiatric disease, severely decreases the life quality of individuals and brings heavy burdens to the whole society. Currently, some antidepressants are applied in the treatment of severe depressive symptoms, while there are still some undesirable drawbacks. Paeoniflorin is a monoterpenoid glycoside that was firstly extracted from Paeonia lactiflora Pall, a traditional Chinese herb that is widely used in the Chinese herbal formulas for treating depression.
This review summarized the previous pre-clinical studies of paeoniflorin in treating depression and further discussed the potential anti-depressive mechanisms for that paeoniflorin to be further explored and utilized in the treatment of depression clinically.
Some electronic databases, e.g., PubMed and China National Knowledge Infrastructure, were searched from inception until April 2021.
This review summarized the effective anti-depressive properties of paeoniflorin, which is related to its functions in the upregulation of the levels of monoaminergic neurotransmitters, inhibition of the hypothalamic-pituitary-adrenal axis hyperfunction, promotion of neuroprotection, promotion of hippocampus neurogenesis, and upregulation of brain-derived neurotrophic factor level, inhibition of inflammatory reaction, downregulation of nitric oxide level, etc. CONCLUSION: This review focused on the pre-clinical studies of paeoniflorin in depression and summarized the recent development of the anti-depressive mechanisms of paeoniflorin, which approves the role of paeoniflorin plays in anti-depression. However, more high-quality pre-clinical and clinical studies are expected to be conducted in the future.
抑郁症作为一种普遍且使人虚弱的精神疾病，严重降低了个体的生活质量，并给整个社会带来了沉重的负担。目前，一些抗抑郁药被应用于严重抑郁症状的治疗，但仍存在一些不理想的缺点。芍药苷是从传统中药白芍中首次提取的一种单萜糖苷，广泛用于治疗抑郁症的中药方剂中。
本综述总结了芍药苷治疗抑郁症的前期临床前研究，并进一步讨论了芍药苷潜在的抗抑郁机制，以期进一步探索和利用芍药苷治疗抑郁症。
检索了一些电子数据库，如 PubMed 和中国知网，检索时间从建库开始到 2021 年 4 月。
本综述总结了芍药苷的有效抗抑郁特性，这与其上调单胺类神经递质水平、抑制下丘脑-垂体-肾上腺轴功能亢进、促进神经保护、促进海马神经发生和上调脑源性神经营养因子水平、抑制炎症反应、下调一氧化氮水平等功能有关。
本综述重点关注了芍药苷在抑郁症中的前期临床前研究，并总结了芍药苷抗抑郁作用的最新机制研究进展，证实了芍药苷在抗抑郁方面的作用。然而，未来仍需要更多高质量的临床前和临床研究。
