Le Sihua, Wu Xuan, Dou Yuan, Song Tianhao, Fu Hongyang, Luo Hongbin, Zhang Fan, Cao Yi
Ningbo Medical Center LiHuiLi Hosptial, Ningbo, China.
The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Front Med (Lausanne). 2024 Sep 4;11:1386783. doi: 10.3389/fmed.2024.1386783. eCollection 2024.
Psoriasis is a chronic, relapsing, inflammatory skin disease and has been increasing year by year. It is linked to other serious illnesses, such as psoriatic arthritis, cardiometabolic syndrome, and depression, resulting in a notable decrease in the quality of life for patients. Existing therapies merely alleviate symptoms, rather than providing a cure. An in-depth under-standing of the pathogenesis of psoriasis is helpful to discover new therapeutic targets and develop effective novel therapeutic agents, so it has important clinical significance. This article reviews the new progress in the study of pathogenesis and natural products of psoriasis in recent years. These natural products were summarized, mainly classified as terpenoids, polyphenols and alkaloids. However, the translation of experimental results to the clinic takes a long way to go.
银屑病是一种慢性、复发性炎症性皮肤病，且其发病率逐年上升。它与其他严重疾病相关，如银屑病关节炎、心脏代谢综合征和抑郁症，导致患者生活质量显著下降。现有疗法仅能缓解症状，而非治愈疾病。深入了解银屑病的发病机制有助于发现新的治疗靶点并开发有效的新型治疗药物，因此具有重要的临床意义。本文综述了近年来银屑病发病机制及天然产物研究的新进展。这些天然产物被总结出来，主要分为萜类、多酚类和生物碱类。然而，将实验结果转化为临床应用仍有很长的路要走。
