Department of Nursing, University Center of Plasencia, University of Extremadura, 10600 Plascencia, Spain.
Department of Medical Sciences, Faculty of Health Sciences, University of Castilla-La Mancha, 45600 Talavera de la Reina, Spain.
Int J Environ Res Public Health. 2021 Dec 19;18(24):13371. doi: 10.3390/ijerph182413371.
Onychomycosis is the main cause of toenail disorders and is produced by a fungal infection. It is becoming more prevalent because of new lifestyles and immunosuppression statuses. The therapeutic approach to onychomycosis is under considerable study because of the lengthy treatments that require strong patient commitment, the limited efficacy of treatments, the inclusion of active substances that can be hepatotoxic and cause pharmacological interactions, and/or the questionable efficacy of treatments due to a lack of clinical trials. This study responds to the demand for rapid treatment with minimal pharmacological interactions.
The efficacy of nitric acid 60% treatment in patients with onychomycosis was monitored and studied. The antifungal efficacy of nitric acid was measured by microbiological culture before and after treatment and the clinical evolution of nail dystrophy was quantitatively measured by monitoring with the Onychomycosis Severity Index (OSI).
The results show that, with the protocol used, nitric acid 60% painlessly cured 40% (microbiologic cure) of the cases treated, and in all cases, clinical improvement was observed ( = 0.011).
The treatment with nitric acid 60% is as efficient as conventional treatments, requires less patient compliance of the treatment and produces no pharmacological interactions, providing alternative treatment in the case of hepatotoxicity.
甲真菌病是引起趾甲紊乱的主要原因，由真菌感染引起。由于新的生活方式和免疫抑制状态，其发病率越来越高。由于治疗需要患者长期坚持、治疗效果有限、包含可能具有肝毒性并引起药物相互作用的活性物质、以及/或由于临床试验不足导致治疗效果存在疑问，因此对甲真菌病的治疗方法正在进行大量研究。本研究旨在满足对具有最小药物相互作用的快速治疗的需求。
监测和研究了 60%硝酸治疗甲真菌病患者的疗效。在治疗前后通过微生物培养来测量硝酸的抗真菌功效，并通过监测甲真菌病严重指数（OSI）来定量测量指甲营养不良的临床演变。
结果表明，使用该方案，60%硝酸无痛治愈了 40%（微生物学治愈）的治疗病例，并且所有病例均观察到临床改善（ = 0.011）。
60%硝酸的治疗与常规治疗一样有效，需要患者对治疗的依从性更低，并且不会产生药物相互作用，在出现肝毒性的情况下提供了替代治疗方法。
