Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine, Japan.
Division of Research Planning and Development, Nihon University School of Medicine, Japan.
Intern Med. 2022 Feb 1;61(3):323-328. doi: 10.2169/internalmedicine.7901-21. Epub 2021 Jul 30.
Celiac disease is a systemic autoimmune disorder leading to manifestations of malabsorption syndrome. A 47-year-old Japanese man developed severe diarrhea after surgery for gastric cancer. The diarrhea persisted for seven months, leading to a state of malabsorption. Celiac disease was suspected based on small bowel capsule endoscopy findings. The duodenal findings observed during gastric cancer surgery were reassessed, and Marsh-Oberhuber classification type 3c celiac disease was diagnosed. The anti-tissue glutaminase antibody test results were positive. The patient was started on a gluten-free diet, following which the diarrhea resolved, and the nutritional status improved. Adjuvant therapy after gastric cancer surgery was initiated.
乳糜泻是一种全身性自身免疫性疾病,可导致吸收不良综合征。一名 47 岁的日本男性在因胃癌接受手术后出现严重腹泻。腹泻持续了七个月,导致吸收不良。根据小肠胶囊内镜检查结果怀疑患有乳糜泻。重新评估了胃癌手术期间观察到的十二指肠发现,并诊断为 Marsh-Oberhuber 分类 3c 乳糜泻。抗组织转谷氨酰胺酶抗体检测结果阳性。患者开始无麸质饮食,腹泻缓解,营养状况改善。胃癌手术后开始辅助治疗。