Ngo Nkondjock Victorine Raïssa, Cheteu Wabo Thérèse Martin, Kosgey Janet Cheruiyot, Zhang Yunlong, Amporfro Daniel Adjei, Adnan Humara, Shah Imran, Li Ying
Department of Nutrition and Food Hygiene, The National Key Discipline, School of Public Health, Harbin Medical University, Harbin, People's Republic of China.
School of Biological Science, Technical University of Kenya, Nairobi, Kenya.
Diabetes Metab Syndr Obes. 2021 Jul 24;14:3361-3373. doi: 10.2147/DMSO.S259409. eCollection 2021.
Recent research suggests the need to assess more ethnic disparities in hypertension (HTN). On the other hand, studies reveal impressive mortality rates due to cardiovascular diseases for some race and ethnic groups compared to others.
We referred to a recent study on serum calcium (SC) and insulin resistance associated with HTN incidence to compare different race groups in the latter found relationship. We compare the current study outcomes with those from the Wu et al study.
From 425 participants of the National Health and Nutrition Examination Survey (NHANES) data, we found a significant association between race and hypertension; Cramer's V (0.006) = 0.21 when adjusted with non-hypertensives and hypertensives. Mc Auley index (McA) was negatively related to hypertension, (355) = -0.24, < 0.0001. SC associated with HTN in all race groups significance persisted only in non-Hispanic Whites after multivariate adjustments of 74.1 ( = 0.03). McA was a mediator on SC-HTN in non-Hispanic Whites (NHW) (Coef = 13.25, [CI] = 1.42-32.13), and a moderator in other Hispanics interaction (0.04) = 0.27 and NHW interaction (0.001) = 0.028.
SC was associated with hypertension, similarly to the baseline study. SC and HTN association persisted in NHW compared to other race groups. Homeostasis model assessment (HOMA-IR) was not a mediator on SC-HTN, but with McA, this in NHW only. McA played a moderator role in OH and NHW. We suggest that race is a factor implicated in our findings, which may be investigated further in future research.
近期研究表明有必要评估高血压（HTN）方面更多的种族差异。另一方面，研究显示某些种族和族裔群体因心血管疾病导致的死亡率相较于其他群体令人印象深刻。
我们参考了一项关于血清钙（SC）与胰岛素抵抗和高血压发病率相关的近期研究，以比较在后者研究中发现的不同种族群体的关系。我们将当前研究结果与Wu等人的研究结果进行比较。
从国家健康和营养检查调查（NHANES）数据的425名参与者中，我们发现种族与高血压之间存在显著关联；在对非高血压者和高血压者进行调整后，克莱默V值（0.006）= 0.21。麦考利指数（McA）与高血压呈负相关，（355）= -0.24，P < 0.0001。在多变量调整后，所有种族群体中与高血压相关的SC仅在非西班牙裔白人中仍具有显著性，为74.1（P = 0.03）。McA在非西班牙裔白人（NHW）中是SC - HTN的中介因素（系数 = 13.25，[置信区间] = 1.42 - 32.13），并且在其他西班牙裔群体的相互作用中是调节因素（0.04）= 0.2及在NHW相互作用中（0.001）= 0.028。
与基线研究类似，SC与高血压相关。与其他种族群体相比，SC与高血压的关联在NHW中持续存在。稳态模型评估（HOMA - IR）不是SC - HTN的中介因素，但仅在NHW中与McA共同作用时是。McA在其他西班牙裔群体和NHW中起调节作用。我们认为种族是我们研究结果中的一个相关因素，未来研究可进一步探究。
