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去甲异欧前胡素促进胱硫醚γ-裂解酶活性，减轻肾脏缺血/再灌注损伤和高血压。

Norswertianolin Promotes Cystathionine γ-Lyase Activity and Attenuates Renal Ischemia/Reperfusion Injury and Hypertension.

作者信息

Niu Yaping, Du Congkuo, Cui Changting, Zhang Haizeng, Deng Yue, Cai Jun, Chen Zhenzhen, Geng Bin

机构信息

Hypertension Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Beijing, China.

Institute of Hypoxia Medicine, Wenzhou Medical University, Wenzhou, China.

出版信息

Front Pharmacol. 2021 Jul 14;12:677212. doi: 10.3389/fphar.2021.677212. eCollection 2021.

DOI:10.3389/fphar.2021.677212
PMID:34335249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8317460/
Abstract

Cystathionine gamma-lyase (CSE)/hydrogen sulfide (HS) plays a protective role in cardiovascular diseases including hypertension and ischemia/reperfusion (I/R) injury. This study was aimed to screen natural small molecule compounds that activate CSE activity and then evaluate its effect(s) on kidney I/R injury and hypertension. Applying computer molecular docking technology, we screened the natural small molecule compound norswertianolin (NW)-specific binding to CSE. Using the microscale thermophoresis technology, we confirmed that the Leu68 site was the essential hydrogen bond site of NW binding to CSE. NW supplementation significantly increased CSE expression and its activity for HS generation both and . In the model of acute and long-term kidney I/R injury, NW pretreatment dramatically attenuated kidney damage, associated with decreasing blood urea nitrogen (BUN), serum creatinine (Cr) level, reactive oxygen species (ROS) production, and cleaved caspase 3 expression. In spontaneously hypertensive rats (SHRs), NW treatment also lowered blood pressure, the media/lumen ratio of the femoral artery, and the mRNA level of inflammatory cytokines. In conclusion, NW acts as a novel small molecular chemical compound CSE agonist, directly binding to CSE, heightening CSE generation-HS activity, and then alleviating kidney I/R injury and hypertension. NW has a potential therapeutic merit for cardiovascular diseases.

摘要

胱硫醚γ-裂解酶（CSE）/硫化氢（HS）在包括高血压和缺血/再灌注（I/R）损伤在内的心血管疾病中发挥保护作用。本研究旨在筛选激活CSE活性的天然小分子化合物，然后评估其对肾脏I/R损伤和高血压的影响。应用计算机分子对接技术，我们筛选出与CSE特异性结合的天然小分子化合物异荭草苷（NW）。使用微量热泳技术，我们证实亮氨酸68位点是NW与CSE结合的关键氢键位点。补充NW显著增加了CSE的表达及其生成HS的活性。在急性和长期肾脏I/R损伤模型中，NW预处理显著减轻了肾脏损伤，这与降低血尿素氮（BUN）、血清肌酐（Cr）水平、活性氧（ROS）生成以及半胱天冬酶3的裂解表达有关。在自发性高血压大鼠（SHR）中，NW治疗还降低了血压、股动脉的中膜/管腔比值以及炎性细胞因子的mRNA水平。总之，NW作为一种新型小分子化合物CSE激动剂，直接与CSE结合，增强CSE生成HS的活性，进而减轻肾脏I/R损伤和高血压。NW对心血管疾病具有潜在的治疗价值。

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本文引用的文献

1
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J Adv Res. 2020 Jun 20;27:115-125. doi: 10.1016/j.jare.2020.06.005. eCollection 2021 Jan.
2
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Circulation. 2020 Nov 3;142(18):1752-1769. doi: 10.1161/CIRCULATIONAHA.119.045344. Epub 2020 Sep 9.
3
Front Cell Dev Biol. 2022 Feb 3;10:829316. doi: 10.3389/fcell.2022.829316. eCollection 2022.
Evolution of Hydrogen Sulfide Therapeutics to Treat Cardiovascular Disease.
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Circ Res. 2018 Aug 17;123(5):590-600. doi: 10.1161/CIRCRESAHA.118.311134.
4
Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension.高血压时传导和阻力动脉的血管平滑肌重塑。
Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):1969-1985. doi: 10.1161/ATVBAHA.118.311229.
5
Sulfhydrated Sirtuin-1 Increasing Its Deacetylation Activity Is an Essential Epigenetics Mechanism of Anti-Atherogenesis by Hydrogen Sulfide.巯基化 Sirtuin-1 增加其去乙酰化活性是硫化氢抗动脉粥样硬化形成的重要表观遗传机制。
Antioxid Redox Signal. 2019 Jan 10;30(2):184-197. doi: 10.1089/ars.2017.7195. Epub 2018 Feb 26.
6
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7
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9
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10
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