Ebisuno S, Morimoto S, Yoshida T, Fukatani T, Yasukawa S, Ohkawa T
Department of Urology, Wakayama Medical College, Japan.
Urol Int. 1987;42(5):330-7. doi: 10.1159/000281987.
Oral administration of ethylene glycol to rats, and the resultant intratubular depositions of microcrystals of calcium oxalate were studied investigating the influences of dietary calcium or magnesium and assessing the protective efficacies against the crystallizations by treatment with phytin and sodium citrate. With increase of calcium intake and consequent increase of urinary calcium excretion there was a marked increase in the amount of tubular deposit of calcium oxalate crystal and in the calcium content of renal tissue. Although magnesium deficiency accelerated renal tubular calcium oxalate deposition, the protection against the crystal formation was not observed with excessive dietary magnesium. When rats were fed a high-calcium diet supplemented with phytin, a significant inhibition of the intratubular crystallization was observed. It appeared obvious that a hypocalciuric action of phytin was attributed to the effect of the prevention. There was vigorous protection of crystal formation by treatment with sodium citrate, which correlated with the level of citrate concentration in the drinking water.
研究了给大鼠口服乙二醇以及由此导致的草酸钙微晶在肾小管内的沉积情况，调查了膳食钙或镁的影响，并评估了用肌醇六磷酸和柠檬酸钠处理对结晶的保护效果。随着钙摄入量的增加以及随之而来的尿钙排泄量的增加，草酸钙晶体在肾小管内的沉积量以及肾组织中的钙含量显著增加。尽管镁缺乏会加速肾小管草酸钙沉积，但过量摄入膳食镁并未观察到对晶体形成的保护作用。当给大鼠喂食添加了肌醇六磷酸的高钙饮食时，观察到肾小管内结晶有显著抑制。很明显，肌醇六磷酸的低钙尿作用归因于其预防效果。用柠檬酸钠处理对晶体形成有很强的保护作用，这与饮用水中柠檬酸盐浓度水平相关。
