Khan S R, Shevock P N, Hackett R L
Department of Pathology, College of Medicine, University of Florida, Gainesville 32610-0275.
J Urol. 1993 Feb;149(2):412-6. doi: 10.1016/s0022-5347(17)36106-2.
We studied the effect of oral administration of magnesium oxide (MgO) on calcium oxalate (CaOx) nephrolithiasis in rats. Nephrolithiasis was induced by administration of 1.0% ethylene glycol (EG) in drinking water. Magnesium oxide was given mixed with food at 500 mg./100 g. rat chow. Dispensation of MgO resulted in a significant increase of urinary pH and a modest increase in urinary excretion of citrate. Urinary excretion of oxalate started to decline by day 14 and was significantly reduced on days 21 and 28. All rats receiving EG displayed crystalluria. From the group receiving EG only, 3 of 4 rats sacrificed on day 15 and 2 of 4 rats sacrificed on day 29 had CaOx crystal deposits in their kidneys. None of the 8 rats who received both EG and MgO had CaOx nephrolithiasis. Thus our findings indicate that dispensation of magnesium as MgO can be beneficial against calcium oxalate nephrolithiasis.
我们研究了口服氧化镁（MgO）对大鼠草酸钙（CaOx）肾结石形成的影响。通过在饮用水中给予1.0%的乙二醇（EG）诱导肾结石形成。将氧化镁与食物混合，按500毫克/100克大鼠饲料的比例给予。给予氧化镁导致尿pH值显著升高，尿枸橼酸盐排泄适度增加。草酸尿排泄在第14天开始下降，并在第21天和第28天显著减少。所有接受乙二醇的大鼠均出现晶体尿。仅接受乙二醇的组中，在第15天处死的4只大鼠中有3只，在第29天处死的4只大鼠中有2只在其肾脏中有草酸钙晶体沉积。接受乙二醇和氧化镁的8只大鼠中没有一只发生草酸钙肾结石。因此，我们的研究结果表明，以氧化镁形式给予镁对草酸钙肾结石可能有益。
