Ruskova M
Vet Med Nauki. 1977;14(9):67-71.
A soluble cell fraction (cytosol), an O-antigen (endotoxin), and an unsoluble cell ingredient were isolated from a 24-hour culture of Escherichia coli O138:K81:H19. Their immunosuppressive action was determined by using the tuberculin test and the survival rate of the allographts. It was found that: 1. Cytosol appears to be a slightly toxic preparation with well expressed immunosuppressive action. 2. The endotoxin is highly toxic, producing the same effect as cytosol. 3. The unsoluble cell ingredient is a comparatively toxic preparation, producing an undependable immunosuppressive effect. Discussed is the mechanism of the immunosuppressive activity of the investigated subcellular fractions. It believed to be due to a certain injurious action on the function of the T-cells.
从大肠杆菌O138:K81:H19的24小时培养物中分离出一种可溶性细胞组分（胞质溶胶）、一种O抗原（内毒素）和一种不溶性细胞成分。通过结核菌素试验和异体移植物的存活率来测定它们的免疫抑制作用。结果发现：1. 胞质溶胶似乎是一种毒性稍低但免疫抑制作用明显的制剂。2. 内毒素毒性很强，产生与胞质溶胶相同的效果。3. 不溶性细胞成分是一种毒性相对较大的制剂，产生不可靠的免疫抑制作用。文中讨论了所研究的亚细胞组分免疫抑制活性的机制。认为这是由于对T细胞功能有某种损伤作用。
