• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

芒果苷通过抑制miR-27b和miR-92a来抑制人肺腺癌。

Mangiferin Inhibits Human Lung Adenocarcinoma by Suppressing MiR-27b and MiR-92a.

作者信息

Chi Xiao-Jv, Meng Jian-Jun, Lin Chun-Yu, Su Qi-Sheng, Qin Yuan-Yuan, Wei Ru-Hua, Lan Dong, Huang Chao

机构信息

Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region 530021, China.

Department of Geriatrics, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region 530021, China.

出版信息

Evid Based Complement Alternat Med. 2021 Jul 12;2021:2822950. doi: 10.1155/2021/2822950. eCollection 2021.

DOI:10.1155/2021/2822950
PMID:34335801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8292060/
Abstract

Lung adenocarcinoma (LUAD) is one of the most prevalent malignancies. However, its mechanism and therapeutic strategy remain to be clarified. Mangiferin is a flavonoid derived from the leaves of mango trees of the lacquer family that has many pharmacological and physiological effects. This research aimed to elucidate the biological effect of mangiferin in LUAD cell lines and clarify the in vitro mechanism of mangiferin. Mangiferin was shown to significantly restrain the proliferation of LUAD cells (A549, H1299, and H2030 cells) in a dose- and time-dependent manner. Furthermore, mangiferin was capable of stimulating apoptosis, and more cells were blocked in G1 and S phase in the mangiferin-treated cells than in those not treated with mangiferin. Microarrays and micro-RNA sequencing data suggested that there is a higher level of miR-27b and miR-92a in LUAD tissues than in non-LUAD tissues. Additional experiments indicated that mangiferin may be related to the downregulated levels of miR-92a and miR-27b. In conclusion, mangiferin likely regulates proliferation and apoptosis in LUAD cells by reducing the expression levels of miR-92a and miR-27b.

摘要

肺腺癌（LUAD）是最常见的恶性肿瘤之一。然而，其发病机制和治疗策略仍有待阐明。芒果苷是一种从漆树科芒果树叶子中提取的黄酮类化合物，具有多种药理和生理作用。本研究旨在阐明芒果苷对LUAD细胞系的生物学效应，并阐明芒果苷的体外作用机制。结果表明，芒果苷能以剂量和时间依赖性方式显著抑制LUAD细胞（A549、H1299和H2030细胞）的增殖。此外，芒果苷能够诱导细胞凋亡，与未用芒果苷处理的细胞相比，经芒果苷处理的细胞中更多细胞被阻滞在G1期和S期。基因芯片和微小RNA测序数据表明，LUAD组织中miR-27b和miR-92a的水平高于非LUAD组织。进一步实验表明，芒果苷可能与miR-92a和miR-27b水平下调有关。总之，芒果苷可能通过降低miR-92a和miR-27b的表达水平来调节LUAD细胞的增殖和凋亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/c6332001ef9d/ECAM2021-2822950.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/c09e20613aba/ECAM2021-2822950.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/0c6e2214a7d6/ECAM2021-2822950.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/aab867e30887/ECAM2021-2822950.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/c1496060a57e/ECAM2021-2822950.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/191587180cd6/ECAM2021-2822950.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/755948595535/ECAM2021-2822950.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/c6332001ef9d/ECAM2021-2822950.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/c09e20613aba/ECAM2021-2822950.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/0c6e2214a7d6/ECAM2021-2822950.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/aab867e30887/ECAM2021-2822950.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/c1496060a57e/ECAM2021-2822950.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/191587180cd6/ECAM2021-2822950.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/755948595535/ECAM2021-2822950.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d829/8292060/c6332001ef9d/ECAM2021-2822950.007.jpg

相似文献

1
Mangiferin Inhibits Human Lung Adenocarcinoma by Suppressing MiR-27b and MiR-92a.芒果苷通过抑制miR-27b和miR-92a来抑制人肺腺癌。
Evid Based Complement Alternat Med. 2021 Jul 12;2021:2822950. doi: 10.1155/2021/2822950. eCollection 2021.
2
Circle RNA FOXP1 promotes cell proliferation in lung cancer by regulating miR-185-5p/Wnt1 signaling pathway.环状 RNA FOXP1 通过调控 miR-185-5p/Wnt1 信号通路促进肺癌细胞增殖。
Eur Rev Med Pharmacol Sci. 2020 Jun;24(12):6767-6778. doi: 10.26355/eurrev_202006_21665.
3
Mangiferin regulates proliferation and apoptosis in glioma cells by induction of microRNA-15b and inhibition of MMP-9 expression.芒果苷通过诱导微小RNA-15b和抑制基质金属蛋白酶-9的表达来调节胶质瘤细胞的增殖和凋亡。
Oncol Rep. 2015 Jun;33(6):2815-20. doi: 10.3892/or.2015.3919. Epub 2015 Apr 21.
4
Sp1-induced upregulation of the long noncoding RNA TINCR inhibits cell migration and invasion by regulating miR-107/miR-1286 in lung adenocarcinoma.Sp1诱导的长链非编码RNA TINCR上调通过调控肺腺癌中的miR-107/miR-1286来抑制细胞迁移和侵袭。
Am J Transl Res. 2019 Aug 15;11(8):4761-4775. eCollection 2019.
5
MiR-188 inhibits proliferation and promotes apoptosis of lung adenocarcinoma cells by targeting SIX1 to negatively regulate ERK signaling pathway.miR-188 通过靶向 SIX1 负向调控 ERK 信号通路抑制肺腺癌细胞的增殖并促进其凋亡。
Eur Rev Med Pharmacol Sci. 2020 Jan;24(2):721-727. doi: 10.26355/eurrev_202001_20051.
6
miR-186-5p promotes cell growth, migration and invasion of lung adenocarcinoma by targeting PTEN.miR-186-5p 通过靶向 PTEN 促进肺腺癌细胞的生长、迁移和侵袭。
Exp Mol Pathol. 2019 Jun;108:105-113. doi: 10.1016/j.yexmp.2019.04.007. Epub 2019 Apr 11.
7
MiR-1-3p Inhibits Lung Adenocarcinoma Cell Tumorigenesis via Targeting Protein Regulator of Cytokinesis 1.微小RNA-1-3p通过靶向细胞分裂调控蛋白1抑制肺腺癌细胞的肿瘤发生。
Front Oncol. 2019 Mar 1;9:120. doi: 10.3389/fonc.2019.00120. eCollection 2019.
8
The LncRNA NEAT1 Accelerates Lung Adenocarcinoma Deterioration and Binds to Mir-193a-3p as a Competitive Endogenous RNA.长链非编码RNA NEAT1通过作为竞争性内源RNA与Mir-193a-3p结合来加速肺腺癌恶化。
Cell Physiol Biochem. 2018;48(3):905-918. doi: 10.1159/000491958. Epub 2018 Jul 23.
9
MicroRNA-147b promotes lung adenocarcinoma cell aggressiveness through negatively regulating microfibril-associated glycoprotein 4 (MFAP4) and affects prognosis of lung adenocarcinoma patients.微小 RNA-147b 通过负调控微纤维相关糖蛋白 4（MFAP4）促进肺腺癌细胞侵袭转移，并影响肺腺癌患者的预后。
Gene. 2020 Mar 10;730:144316. doi: 10.1016/j.gene.2019.144316. Epub 2019 Dec 26.
10
LncRNA GMDS-AS1 inhibits lung adenocarcinoma development by regulating miR-96-5p/CYLD signaling.长链非编码 RNA GMDS-AS1 通过调控 miR-96-5p/CYLD 信号通路抑制肺腺癌的发展。
Cancer Med. 2020 Feb;9(3):1196-1208. doi: 10.1002/cam4.2776. Epub 2019 Dec 20.

引用本文的文献

1
Mangiferin: An effective agent against human malignancies.芒果苷：一种抗人类恶性肿瘤的有效药物。
Food Sci Nutr. 2024 Sep 8;12(10):7137-7157. doi: 10.1002/fsn3.4434. eCollection 2024 Oct.
2
Bioactive components and the molecular mechanism of Shengxian Decoction against lung adenocarcinoma based on network pharmacology and molecular docking.基于网络药理学和分子对接的升仙汤抗肺腺癌生物活性成分及分子机制研究
Am J Transl Res. 2023 Dec 15;15(12):6988-7012. eCollection 2023.
3
Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways.

本文引用的文献

1
Phytochemical Profile, Antioxidant Capacity, α-Amylase and α-Glucosidase Inhibitory Potential of Wild Moroccan (L.) Leaves.野生摩洛哥（L.）叶的植物化学成分分析、抗氧化能力、α-淀粉酶和α-葡萄糖苷酶抑制潜力。
Molecules. 2021 May 24;26(11):3134. doi: 10.3390/molecules26113134.
2
Anticancer Effects of Lingonberry and Bilberry on Digestive Tract Cancers.越橘和欧洲越橘对消化道癌症的抗癌作用。
Antioxidants (Basel). 2021 May 26;10(6):850. doi: 10.3390/antiox10060850.
3
miR-27b Suppresses Tongue Squamous Cell Carcinoma Epithelial-Mesenchymal Transition by Targeting ITGA5.
芒果苷通过调节信号转导通路在癌症治疗中的作用
Biomedicines. 2023 Dec 1;11(12):3205. doi: 10.3390/biomedicines11123205.
4
Connection between Radiation-Regulating Functions of Natural Products and miRNAs Targeting Radiomodulation and Exosome Biogenesis.天然产物的辐射调节功能与靶向辐射调节和外泌体生物发生的 miRNAs 之间的联系。
Int J Mol Sci. 2023 Aug 4;24(15):12449. doi: 10.3390/ijms241512449.
5
Chemical and Biological Evidence of the Efficacy of Shengxian Decoction for Treating Human Lung Adenocarcinoma.升仙汤治疗人肺腺癌疗效的化学与生物学证据
Front Oncol. 2022 Mar 18;12:849579. doi: 10.3389/fonc.2022.849579. eCollection 2022.
微小RNA-27b通过靶向整合素α5抑制舌鳞状细胞癌上皮-间质转化
Onco Targets Ther. 2020 Nov 17;13:11855-11867. doi: 10.2147/OTT.S281211. eCollection 2020.
4
Tumor-suppressor miRNA-27b-5p regulates the growth and metastatic behaviors of ovarian carcinoma cells by targeting CXCL1.抑癌 miRNA-27b-5p 通过靶向 CXCL1 调节卵巢癌细胞的生长和转移行为。
J Ovarian Res. 2020 Aug 11;13(1):92. doi: 10.1186/s13048-020-00697-6.
5
Circulating miR-16-5p, miR-92a-3p, and miR-451a in Plasma from Lung Cancer Patients: Potential Application in Early Detection and a Regulatory Role in Tumorigenesis Pathways.肺癌患者血浆中循环miR-16-5p、miR-92a-3p和miR-451a：在早期检测中的潜在应用及在肿瘤发生途径中的调控作用
Cancers (Basel). 2020 Jul 27;12(8):2071. doi: 10.3390/cancers12082071.
6
Mangiferin inhibits lipopolysaccharide-induced epithelial-mesenchymal transition (EMT) and enhances the expression of tumor suppressor gene PER1 in non-small cell lung cancer cells.芒果苷抑制脂多糖诱导的非小细胞肺癌上皮-间充质转化（EMT），并增强抑癌基因 PER1 的表达。
Environ Toxicol. 2020 Oct;35(10):1070-1081. doi: 10.1002/tox.22943. Epub 2020 May 18.
7
Mangiferin Alleviates Ovalbumin-Induced Allergic Rhinitis via Nrf2/HO-1/NF-κB Signaling Pathways.芒果苷通过 Nrf2/HO-1/NF-κB 信号通路缓解卵清蛋白诱导的变应性鼻炎。
Int J Mol Sci. 2020 May 12;21(10):3415. doi: 10.3390/ijms21103415.
8
miRNAs as potential biomarkers for the progression of gastric cancer inhibit CREBZF and regulate migration of gastric adenocarcinoma cells.miRNAs 作为胃癌进展的潜在生物标志物，抑制 CREBZF 并调节胃腺癌细胞的迁移。
Int J Med Sci. 2020 Feb 24;17(6):693-701. doi: 10.7150/ijms.42654. eCollection 2020.
9
Curcumin Has Anti-Proliferative and Pro-Apoptotic Effects on Tongue Cancer in vitro: A Study with Bioinformatics Analysis and in vitro Experiments.姜黄素对体外舌癌细胞具有抗增殖和促凋亡作用：生物信息学分析和体外实验研究。
Drug Des Devel Ther. 2020 Feb 4;14:509-518. doi: 10.2147/DDDT.S237830. eCollection 2020.
10
Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival.泛癌症分析揭示了调控肿瘤发生和患者生存的 miRNA 双链的协同作用。
Nat Commun. 2020 Feb 20;11(1):968. doi: 10.1038/s41467-020-14713-2.