垂直骨增量的动物模型（综述）
Animal models of vertical bone augmentation (Review).
作者信息
Zhang Zepeng, Gan Yaxin, Guo Yarong, Lu Xuguang, Li Xianqi
机构信息
Department of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, Shanxi 030001, P.R. China.
Department of Oral and Maxillofacial Surgery, School of Dentistry, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan.
出版信息
Exp Ther Med. 2021 Sep;22(3):919. doi: 10.3892/etm.2021.10351. Epub 2021 Jun 30.
Abstract
Vertical bone augmentation is an important challenge in dental implantology. Existing vertical bone augmentation techniques, along with bone grafting materials, have achieved certain clinical progress but continue to have numerous limitations. In order to evaluate the possibility of using biomaterials to develop bone substitutes, medical devices and/or new bone grafting techniques for vertical bone augmentation, it is essential to establish clinically relevant animal models to investigate their biocompatibility, mechanical properties, applicability and safety. The present review discusses recent animal experiments related to vertical bone augmentation. In addition, surgical protocols for establishing relevant preclinical models with various animal species were reviewed. The present study aims to provide guidance for selecting experimental animal models of vertical bone augmentation.
摘要
垂直骨增量是牙种植学中的一项重要挑战。现有的垂直骨增量技术以及骨移植材料已取得了一定的临床进展，但仍存在诸多局限性。为了评估使用生物材料开发用于垂直骨增量的骨替代物、医疗器械和/或新的骨移植技术的可能性，建立与临床相关的动物模型以研究其生物相容性、力学性能、适用性和安全性至关重要。本综述讨论了近期与垂直骨增量相关的动物实验。此外，还综述了使用各种动物建立相关临床前模型的手术方案。本研究旨在为选择垂直骨增量的实验动物模型提供指导。
相似文献
1
Animal models of vertical bone augmentation (Review).垂直骨增量的动物模型（综述）
Exp Ther Med. 2021 Sep;22(3):919. doi: 10.3892/etm.2021.10351. Epub 2021 Jun 30.
2
The efficacy of horizontal and vertical bone augmentation procedures for dental implants - a Cochrane systematic review.用于牙种植体的水平和垂直骨增量手术的疗效——一项Cochrane系统评价
Eur J Oral Implantol. 2009 Autumn;2(3):167-84.
3
Bone defect animal models for testing efficacy of bone substitute biomaterials.用于测试骨替代生物材料功效的骨缺损动物模型。
J Orthop Translat. 2015 Jun 16;3(3):95-104. doi: 10.1016/j.jot.2015.05.002. eCollection 2015 Jul.
4
Vertical bone augmentation procedures: basics and techniques in dental implantology.垂直骨增量手术：牙种植学的基础与技术
J Biomed Mater Res A. 2014 May;102(5):1605-13. doi: 10.1002/jbm.a.34812. Epub 2013 Jun 11.
5
Vertical Ridge Gain with Various Bone Augmentation Techniques: A Systematic Review and Meta-Analysis.各种骨增量技术的垂直骨增量：系统评价和荟萃分析。
J Prosthodont. 2019 Apr;28(4):421-427. doi: 10.1111/jopr.13028. Epub 2019 Feb 13.
6
Vertical bone augmentation: where are we now?垂直骨增量：我们目前的进展如何？
Implant Dent. 2006 Sep;15(3):219-28. doi: 10.1097/01.id.0000226824.39526.71.
7
Vertical ridge augmentation using guided bone regeneration (GBR) in three clinical scenarios prior to implant placement: a retrospective study of 35 patients 12 to 72 months after loading.种植体植入前三种临床情况下使用引导骨再生术（GBR）进行垂直骨嵴增高：对35例患者负重后12至72个月的回顾性研究
Int J Oral Maxillofac Implants. 2009 May-Jun;24(3):502-10.
8
Island osteoperiosteal flaps with interpositional bone grafting in rabbit tibia: preliminary study for development of new bone augmentation technique.兔胫骨带植入性骨移植的岛状骨膜瓣：新型骨增量技术开发的初步研究
J Oral Maxillofac Surg. 2011 Dec;69(12):3045-51. doi: 10.1016/j.joms.2010.12.051. Epub 2011 May 6.
9
Biomaterial selection for bone augmentation in implant dentistry: A systematic review.种植牙学中骨增量的生物材料选择：一项系统评价
J Adv Pharm Technol Res. 2019 Apr-Jun;10(2):46-50. doi: 10.4103/japtr.JAPTR_327_18.
10
Dimensional alterations following vertical ridge augmentation using collagen membrane and three types of bone grafting materials: A retrospective observational study.采用胶原膜和三种骨移植材料进行垂直骨嵴增加后的维度改变：一项回顾性观察研究。
Clin Implant Dent Relat Res. 2017 Aug;19(4):742-749. doi: 10.1111/cid.12502. Epub 2017 May 29.
引用本文的文献
1
Effectiveness of bone expansion, compacting and densification in narrow alveolar crests: a systematic review and a meta-analysis.窄牙槽嵴中骨扩张、挤压和致密化的有效性：一项系统评价和荟萃分析。
Front Bioeng Biotechnol. 2025 Jun 25;13:1630495. doi: 10.3389/fbioe.2025.1630495. eCollection 2025.
2
The Interplay of Angiogenesis and Osteogenesis in Non-Stabilized Incomplete Tibial Fractures: A Temporal Study in Rats.非稳定性胫骨不完全骨折中血管生成与骨生成的相互作用：大鼠的一项时间性研究
J Orthop Res. 2025 Sep;43(9):1632-1646. doi: 10.1002/jor.70006. Epub 2025 Jun 20.
3
Optimizing the Handling of Cancellous Bone Grafts to Preserve Their Osteogenic Potential in Craniofacial Surgery.优化松质骨移植物的处理以保留其在颅面外科手术中的成骨潜力。
Int J Mol Sci. 2025 Apr 30;26(9):4255. doi: 10.3390/ijms26094255.
4
An evaluation of novel AMP2-coated electrospun composite scaffolds for intraoral bone regeneration: a proof-of-concept study.新型AMP2涂层电纺复合支架用于口腔内骨再生的评估：一项概念验证研究。
Front Bioeng Biotechnol. 2025 Apr 17;13:1443280. doi: 10.3389/fbioe.2025.1443280. eCollection 2025.
5
In vivo validation of highly customized cranial Ti-6AL-4V ELI prostheses fabricated through incremental forming and superplastic forming: an ovine model study.通过增量成形和超塑成形制造的高度定制化颅 Ti-6AL-4VELI 假体的体内验证：绵羊模型研究。
Sci Rep. 2024 Apr 4;14(1):7959. doi: 10.1038/s41598-024-57629-3.
6
The impact of immediate versus delayed mini-screw placement on alveolar bone preservation and bone density following tooth extraction: evidence from a canine model.即刻与延迟放置微型种植体对拔牙后牙槽骨保存和骨密度的影响：犬模型的证据。
BMC Oral Health. 2023 Dec 6;23(1):972. doi: 10.1186/s12903-023-03703-7.
7
Bone Grafts in Dental Medicine: An Overview of Autografts, Allografts and Synthetic Materials.牙科医学中的骨移植：自体移植、异体移植和合成材料概述
Materials (Basel). 2023 May 31;16(11):4117. doi: 10.3390/ma16114117.
8
Lateral Bone Augmentation Using a Three-Dimensional-Printed Polymeric Chamber to Compare Biomaterials.侧向骨增量使用三维打印聚合物室比较生物材料。
Tissue Eng Part C Methods. 2023 Jul;29(7):287-297. doi: 10.1089/ten.TEC.2023.0025. Epub 2023 May 24.
9
本文引用的文献
1
Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold.还原氧化石墨烯增强锌支架的微观结构演变与织构调控
Bioact Mater. 2020 Nov 7;6(5):1230-1241. doi: 10.1016/j.bioactmat.2020.10.017. eCollection 2021 May.
2
Microstructural volumetric analysis of vertical alveolar ridge augmentation using autogenous tooth roots.自体牙根用于垂直牙槽嵴增量的微观结构体积分析。
Clin Implant Dent Relat Res. 2020 Oct;22(5):647-653. doi: 10.1111/cid.12947. Epub 2020 Sep 2.
3
Synergism between recombinant human bone morphogenetic protein 2/absorbable collagen sponge and bone substitutes favors vertical bone augmentation and the resorption rate of the biomaterials: Histomorphometric and 3D microcomputed tomography analysis.重组人骨形态发生蛋白 2/可吸收胶原海绵与骨替代物之间的协同作用有利于垂直骨增量和生物材料的吸收率：组织形态计量学和 3D 微计算机断层扫描分析。
J Periodontol. 2020 Oct;91(10):1295-1306. doi: 10.1002/JPER.19-0571. Epub 2020 Mar 25.
4
Osseous ingrowth in allogeneic bone blocks applied for vertical bone augmentation: a preclinical randomised controlled study.异体骨块用于垂直骨增量的骨内生长：一项临床前随机对照研究。
Clin Oral Investig. 2020 Aug;24(8):2867-2879. doi: 10.1007/s00784-019-03151-0. Epub 2019 Dec 11.
5
Vertical bone augmentation with simultaneous implantation using deproteinized bovine bone block functionalized with a slow delivery of BMP-2.使用功能化的脱蛋白牛骨块进行垂直骨增量，并同时进行骨形态发生蛋白 2 的缓慢释放植入。
Clin Oral Implants Res. 2020 Mar;31(3):215-228. doi: 10.1111/clr.13558. Epub 2020 Jan 13.
6
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials.用于评估骨替代材料中骨生长和新生血管形成的兔颅骨骨增量模型
J Vis Exp. 2019 Aug 13(150). doi: 10.3791/59976.
7
Bone augmentation using small molecules with biodegradable calcium sulfate particles in a vertical onlay graft model in the rabbit calvarium.在兔颅骨垂直覆盖移植模型中，使用小分子与可生物降解硫酸钙颗粒进行骨增量。
J Biomed Mater Res B Appl Biomater. 2020 May;108(4):1343-1350. doi: 10.1002/jbm.b.34483. Epub 2019 Aug 30.
8
The minipig as a potential model for pedicle screw fixation: morphometry and mechanics.小型猪作为椎弓根螺钉固定的潜在模型：形态测量学和力学。
J Orthop Surg Res. 2019 Aug 5;14(1):246. doi: 10.1186/s13018-019-1292-9.
9
Histomorphometrical assessment of vertical alveolar ridge augmentation using extracted tooth roots in the canine.应用于犬牙的拔除牙根进行垂直牙槽嵴增高的组织形态计量学评估。
Clin Oral Investig. 2020 Jan;24(1):317-323. doi: 10.1007/s00784-019-02960-7. Epub 2019 May 17.
10
Bone Augmentation and Simultaneous Implant Placement with Allogenic Bone Rings and Analysis of Its Purification Success.同种异体骨环用于骨增量及同期种植体植入及其纯化成功率分析
Materials (Basel). 2019 Apr 19;12(8):1291. doi: 10.3390/ma12081291.
Zotero 插件