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通过增量成形和超塑成形制造的高度定制化颅 Ti-6AL-4VELI 假体的体内验证：绵羊模型研究。

In vivo validation of highly customized cranial Ti-6AL-4V ELI prostheses fabricated through incremental forming and superplastic forming: an ovine model study.

机构信息

Scienze e Tecnologie Chirurgiche, IRCCS Istituto Ortopedico Rizzoli, Via Di Barbiano, 1/10, Bologna, Italy.

Dipartimento di Medicina Veterinaria, Università di Sassari, Via Vienna 2, 07100, Sassari, Italy.

出版信息

Sci Rep. 2024 Apr 4;14(1):7959. doi: 10.1038/s41598-024-57629-3.

DOI:10.1038/s41598-024-57629-3
PMID:38575608
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10995190/
Abstract

Cranial reconstructions are essential for restoring both function and aesthetics in patients with craniofacial deformities or traumatic injuries. Titanium prostheses have gained popularity due to their biocompatibility, strength, and corrosion resistance. The use of Superplastic Forming (SPF) and Single Point Incremental Forming (SPIF) techniques to create titanium prostheses, specifically designed for cranial reconstructions was investigated in an ovine model through microtomographic and histomorphometric analyses. The results obtained from the explanted specimens revealed significant variations in bone volume, trabecular thickness, spacing, and number across different regions of interest (VOIs or ROIs). Those regions next to the center of the cranial defect exhibited the most immature bone, characterized by higher porosity, decreased trabecular thickness, and wider trabecular spacing. Dynamic histomorphometry demonstrated differences in the mineralizing surface to bone surface ratio (MS/BS) and mineral apposition rate (MAR) depending on the timing of fluorochrome administration. A layer of connective tissue separated the prosthesis and the bone tissue. Overall, the study provided validation for the use of cranial prostheses made using SPF and SPIF techniques, offering insights into the processes of bone formation and remodeling in the implanted ovine model.

摘要

颅骨重建对于恢复颅面畸形或创伤患者的功能和美学至关重要。由于钛的生物相容性、强度和耐腐蚀性，钛假体已得到广泛应用。本研究通过微断层扫描和组织形态计量学分析，研究了在绵羊模型中使用超塑成形（SPF）和单点增量成形（SPIF）技术来制造专门用于颅骨重建的钛假体。从植入标本中获得的结果表明，不同感兴趣区域（VOI 或 ROI）的骨量、骨小梁厚度、间隔和数量存在显著差异。靠近颅骨缺损中心的区域表现出最不成熟的骨骼，其特征是更高的孔隙率、骨小梁厚度减小和更宽的骨小梁间隔。动态组织形态计量学显示，根据荧光标记物给药时间的不同，矿化表面与骨表面比（MS/BS）和矿化沉积率（MAR）存在差异。一层结缔组织将假体和骨组织隔开。总的来说，该研究为使用 SPF 和 SPIF 技术制造的颅骨假体的应用提供了验证，并深入了解了植入绵羊模型中骨形成和重塑的过程。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c30/10995190/08307f5f7dc9/41598_2024_57629_Fig11_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c30/10995190/3fbe233215a8/41598_2024_57629_Fig13_HTML.jpg

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