Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430000, China.
School of Economics and Management, China University of Geosciences (Wuhan), Wuhan 430000, China.
J Healthc Eng. 2021 Jul 22;2021:4505227. doi: 10.1155/2021/4505227. eCollection 2021.
This study uses PET imaging to observe the uptake and metabolism of 18F-fluorodeoxyglucose (F-FDG) in the multibrain areas of the emotional control loop in patients with generalized anxiety disorder (GAD) and investigate the brain of GAD patient's functional abnormality mechanism.
The thesis clinically collected 20 GAD patients and 20 healthy subjects. Dynamic PET-CT scans were used. At the same time, F-FDG whole-brain uptake and metabolism data were collected. Image fusion and semiquantitative analysis were used to measure emotional control loops. The maximum standard uptake value (SUVmax) and dynamic uptake and metabolic changes of 11 time points in the brain area at 150 min were measured.
Compared with the healthy control group, the peak uptake of the bilateral prefrontal cortex and the average uptake rate before the peak in GAD patients were significantly reduced ( < 0.05), and the average metabolic rate after the peak was significantly increased ( < 0.05). The peak uptake of the left striatum and the left hippocampus, the average uptake rate before the peak, and the average metabolic rate after the peak were all significantly reduced ( < 0.05); There were no obvious changes in the three indexes of the right striatum and the right hippocampus.
There are F-FDG uptake and metabolic disorders in multiple brain areas of the affective control loop of GAD patients. The abnormal peak and rate of uptake may be related to the pathogenesis of GAD.
本研究采用 PET 成像观察广泛性焦虑障碍（GAD）患者情绪控制回路多脑区对 18F-氟脱氧葡萄糖（F-FDG）的摄取和代谢情况，探讨 GAD 患者脑功能异常的发生机制。
本论文临床收集了 20 例 GAD 患者和 20 例健康对照者。使用动态 PET-CT 扫描，同时采集 F-FDG 全脑摄取和代谢数据。采用图像融合和半定量分析方法测量情绪控制回路，测量 150min 时脑区的 11 个时间点的最大标准摄取值（SUVmax）和动态摄取及代谢变化。
与健康对照组相比，GAD 患者双侧前额叶皮质的峰值摄取和峰值前的平均摄取率明显降低（<0.05），而峰值后的平均代谢率明显增加（<0.05）；左侧纹状体和左侧海马的峰值摄取、峰值前的平均摄取率和峰值后的平均代谢率均明显降低（<0.05）；右侧纹状体和右侧海马的三个指标均无明显变化。
GAD 患者情绪控制回路多个脑区存在 F-FDG 摄取和代谢异常，摄取的峰值和速率异常可能与 GAD 的发病机制有关。
