Department of Radiology, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, Guangdong, China.
Department of Acupuncture and Moxibustion, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, Guangdong, China.
J Healthc Eng. 2021 Jul 22;2021:5063021. doi: 10.1155/2021/5063021. eCollection 2021.
In this paper, the application of 3-dimensional (3D) functional magnetic resonance imaging (FMRI) in the diagnosis of the 5 lumbar (L5) nerve root compression and brain functional areas in patients with lumbar disc herniation (LDH) was analyzed. The traditional fast independent component analysis (Fast ICA) algorithm was optimized based on the modified whitening matrix to establish a new type of Modified-Fast ICA (M-Fast ICA) algorithm that was compared with the introduced traditional Fast ICA and ICA. M-Fast ICA was applied to the 3D FMRI diffusion tensor imaging (DTI) evaluation of 65 patients with L5 nerve root pain due to LDH (group A) and 50 healthy volunteers (group B). The values of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in the lumbar nerve roots (L3, L4, L5, and the 1 sacral vertebra (S1)) were recorded among subjects from the two groups. Besides, the score of edema degree in the lumbar nerve roots (L5 and S1) and activity of brain functional areas were also recorded among all subjects of the two groups. The results showed that the mean square error of M-Fast ICA was smaller than that of traditional Fast ICA and ICA, while its signal-to-noise ratio (SNR) was greater than that of Fast ICA and ICA ( < 0.05). The FA of L5 and S1 nerve roots in patients of group A was sharply lower than the values of group B, while the ADC of patients in group A was greater than that of the control group ( < 0.05). Besides, the score of edema in L5 and S1 nerve roots of patients in group A increased in contrast to group B ( < 0.05). The brain areas were activated after surgery including bilateral temporal lobe, left thalamus, splenium of corpus callosum, and right internal capsule. In conclusion, the 3D image denoising performance of M-Fast ICA optimized and constructed in this study was superior to that of the traditional Fast ICA and ICA. The FA of patients with L5 nerve root pain due to LDH decreased steeply, while the ADC increased dramatically. L5 nerve root pain caused by LDH resulted in changes in brain functional areas of the patients to inhibit the resting state default network activity, and the corresponding brain functional areas could be activated through treatment.
本文分析了三维（3D）功能磁共振成像（FMRI）在诊断腰椎间盘突出症（LDH）患者 5 腰椎（L5）神经根受压和脑功能区中的应用。基于改进的白化矩阵优化了传统的快速独立成分分析（Fast ICA）算法，建立了一种新型的改进快速独立成分分析（M-Fast ICA）算法，并与引入的传统快速独立成分分析和独立成分分析进行了比较。M-Fast ICA 应用于 65 例因 LDH 引起的 L5 神经根痛患者（A 组）和 50 名健康志愿者（B 组）的 3D FMRI 弥散张量成像（DTI）评估。记录两组受试者腰椎神经根（L3、L4、L5 和 1 骶骨（S1））的分数各向异性（FA）和表观扩散系数（ADC）值。此外，还记录了两组受试者腰椎神经根（L5 和 S1）水肿程度评分和脑功能区活动评分。结果表明，M-Fast ICA 的均方误差小于传统 Fast ICA 和独立成分分析，而其信噪比（SNR）大于 Fast ICA 和独立成分分析（<0.05）。A 组患者 L5 和 S1 神经根的 FA 明显低于 B 组，而 A 组患者的 ADC 大于对照组（<0.05）。此外，A 组患者 L5 和 S1 神经根的水肿评分与 B 组相比有所增加（<0.05）。手术后大脑区域被激活，包括双侧颞叶、左侧丘脑、胼胝体压部和右侧内囊。总之，本研究优化构建的 3D 图像去噪性能优于传统的 Fast ICA 和独立成分分析。LDH 引起的 L5 神经根痛患者的 FA 急剧下降，而 ADC 显著增加。LDH 引起的 L5 神经根痛导致患者脑功能区发生变化，抑制静息状态默认网络活动，通过治疗可激活相应的脑功能区。
