Nukala Swetha, Puvvada Suvarna Rekha, Luvsannyam Enkhmaa, Patel Dhara, Hamid Pousette
Department of Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Department of Research, California Instititute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2021 Jun 28;13(6):e15999. doi: 10.7759/cureus.15999. eCollection 2021 Jun.
Osteoarthritis (OA) is progressive wear and tear disease that affects multiple joints, including knees, hips, and spine. OA causes structural damage to joints. Although hypertension, type II diabetes, and hyperlipidemia have a silent effect, for the most part, the addition of osteoarthritis has a limiting and debilitating impact on patients. Common symptoms of OA include joint pain, joint swelling, limitations in range of motion that is impacting one's quality of life. The question being investigated in this systematic review is whether hyperlipidemia or the use of statin has any effect on osteoarthritis and progression of osteoarthritis. This systematic review of 13 articles was done to explore if there is an effect of hyperlipidemia and statin use on the progression of osteoarthritis. This study included 6,974,538 total participants. Eight studies out of the 13 investigated the effect of statin use. Out of the 13 articles, five studies investigated the impact of lipid levels on OA. The total participants cannot be divided into statin users and non-users because some studies did not divide the participants into two groups. Studies that investigated the effect of lipid levels on OA were studied based on age. Some included only women in their study, and one study was solely conducted in the military population. Therefore, these studies cannot be divided based on age. Further research is needed to significantly conclude either the positive or negative correlation of hyperlipidemia and statin use on osteoarthritis and its progression.
骨关节炎（OA）是一种影响多个关节（包括膝盖、臀部和脊柱）的进行性磨损疾病。OA会对关节造成结构损伤。尽管高血压、II型糖尿病和高脂血症有潜在影响，但在很大程度上，骨关节炎的叠加对患者有限制和衰弱的影响。OA的常见症状包括关节疼痛、关节肿胀、影响生活质量的活动范围受限。本系统评价所研究的问题是高脂血症或他汀类药物的使用是否对骨关节炎及其进展有任何影响。对13篇文章进行了这项系统评价，以探讨高脂血症和他汀类药物的使用对骨关节炎进展是否有影响。这项研究共纳入6974538名参与者。13项研究中有8项研究了他汀类药物使用的影响。在这13篇文章中，有5项研究调查了血脂水平对OA的影响。由于一些研究没有将参与者分为两组，所以无法将总参与者分为他汀类药物使用者和非使用者。研究血脂水平对OA影响的研究是按年龄进行的。有些研究仅纳入女性，还有一项研究仅在军人人群中进行。因此，这些研究无法按年龄进行划分。需要进一步研究才能显著得出高脂血症和他汀类药物使用与骨关节炎及其进展之间的正相关或负相关结论。
