Research Unit, Family Medicine. Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Girona, Spain.
Translab Research Group. Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain.
Sci Rep. 2017 Jun 9;7(1):3147. doi: 10.1038/s41598-017-03317-4.
The development of hand osteoarthritis (HOA) could be linked to hyperlipidaemia. No longitudinal studies have addressed the relationship between serum lipid profile and HOA. The study aim was to determine the association between serum lipid profile and the incidence of radiographic hand osteoarthritis (RHOA). All women in a prospective population-based cohort from the Chingford study with available baseline lipid measurements and without RHOA on a baseline were included. Study outcome was the incidence of RHOA in year 11 of follow-up. Serum lipid profile variables were analysed as continuous variables and categorised into quartiles. The association between serum lipid profile and RHOA was modeled using multivariable logistic regression. Overall RHOA incidence was 51.6% (45.7-57.4%). An inverse association between HDL cholesterol levels and the incidence of RHOA was observed by quartile: OR of 0.36 [95%CI 0.17-0.75], 0.52 [95%CI 0.26-1.06], and 0.48 [95%CI 0.22-1.03]. Triglycerides levels showed a significant trend. No relationship was found with total or LDL cholesterol. Higher levels of HDL cholesterol appear to protect against RHOA after 11 years of follow-up. More research is needed to elucidate HOA risk factors, the mechanisms related to the lipid pathway, and the effects of lipid-lowering agents on reducing the incidence of OA.
手部骨关节炎（HOA）的发展可能与高脂血症有关。尚无纵向研究探讨血清脂质谱与 HOA 之间的关系。本研究旨在确定血清脂质谱与放射学手部骨关节炎（RHOA）发病率之间的关系。所有来自 Chingford 研究的前瞻性人群队列中的女性，均具有基线时可获得的脂质测量值且基线时无 RHOA，均纳入本研究。研究结果为随访 11 年时 RHOA 的发病率。血清脂质谱变量被分析为连续变量，并分为四分位数。使用多变量逻辑回归模型来分析血清脂质谱与 RHOA 之间的关系。总体 RHOA 发病率为 51.6%（45.7-57.4%）。按 quartile 分析，HDL 胆固醇水平与 RHOA 的发病率呈负相关：OR 为 0.36 [95%CI 0.17-0.75]、0.52 [95%CI 0.26-1.06]和 0.48 [95%CI 0.22-1.03]。甘油三酯水平呈显著趋势。与总胆固醇或 LDL 胆固醇无相关性。经过 11 年的随访，较高的 HDL 胆固醇水平似乎可以预防 RHOA。需要进一步的研究来阐明 HOA 的危险因素、与脂质途径相关的机制以及降脂药物对降低 OA 发病率的影响。
