Edwards Penelope, Kang Byung Woog, Chau Ian
Department of Medicine, Royal Marsden Hospital, London, United Kingdom.
Department of Oncology/Hematology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea.
Front Oncol. 2021 Jul 14;11:691185. doi: 10.3389/fonc.2021.691185. eCollection 2021.
Pancreatic cancer (PC) presents extremely aggressive tumours and is associated with poor survival. This is attributed to the unique features of the tumour microenvironment (TME), which is known to create a dense stromal formation and poorly immunogenic condition. In particular, the TME of PC, including the stromal cells and extracellular matrix, plays an essential role in the progression and chemoresistance of PC. Consequently, several promising agents that target key components of the stroma have already been developed and are currently in multiple stages of clinical trials. Therefore, the authors review the latest available evidence on novel stroma-targeting approaches, highlighting the potential impact of the stroma as a key component of the TME in PC.
胰腺癌（PC）具有极具侵袭性的肿瘤，且与生存率低相关。这归因于肿瘤微环境（TME）的独特特征，已知其会形成致密的基质并导致免疫原性较差的状况。特别是，PC的TME，包括基质细胞和细胞外基质，在PC的进展和化疗耐药性中起着至关重要的作用。因此，已经开发了几种靶向基质关键成分的有前景的药物，目前正处于多个临床试验阶段。因此，作者回顾了关于新型基质靶向方法的最新可用证据，强调了基质作为PC中TME关键成分的潜在影响。
