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糖尿病中的非酶糖基化低密度脂蛋白

[Non-enzymatically glycosylated low-density lipoproteins in diabetes mellitus].

作者信息

Tsanev A, Petrova V, Bradistilov S, Petrunova N

出版信息

Vutr Boles. 1987;26(5):83-6.

PMID:3433733
Abstract

In 24 diabetic patients and 23 healthy persons the fatty metabolism was studied (cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol and glycosylated LD-lipoproteins). Iin diabetic patients the glycosylated low density lipoproteins travel from the cathode to the anode at a distance of 37-57 mm and in the control group they travel to a distance of 18-22 mm. In spite of the insignificant differences of cholesterol levels between the diabetics and the control and of the total cholesterol level being in normal ranges, the nonenzymatically glycosylated LD-lipoproteins are in greater quantity in the diabetics which is a predisposing factor for early atherosclerosis. The establishment of a correlation between the blood sugar level and that of the glycosylated LD-lipoproteins in diabetic patients could serve as a criterion for early atherosclerosis.

摘要

对24名糖尿病患者和23名健康人进行了脂肪代谢研究(包括胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇和糖基化低密度脂蛋白)。在糖尿病患者中,糖基化低密度脂蛋白从阴极向阳极移动的距离为37 - 57毫米,而在对照组中,它们移动的距离为18 - 22毫米。尽管糖尿病患者与对照组之间的胆固醇水平差异不显著,且总胆固醇水平处于正常范围,但糖尿病患者中非酶糖基化低密度脂蛋白的数量更多,这是早期动脉粥样硬化的一个诱发因素。确定糖尿病患者血糖水平与糖基化低密度脂蛋白水平之间的相关性可作为早期动脉粥样硬化的一个标准。

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1
[Non-enzymatically glycosylated low-density lipoproteins in diabetes mellitus].糖尿病中的非酶糖基化低密度脂蛋白
Vutr Boles. 1987;26(5):83-6.
2
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