Mansour Ahmed M, Radacki Krzysztof, Shehab Ola R
Department of Chemistry, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt.
Institut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany.
Dalton Trans. 2021 Aug 21;50(31):10701-10706. doi: 10.1039/d1dt00979f. Epub 2021 Aug 2.
Introduction of the propyl-sulfonic acid group at N1 of the coordinated 2-(2-pyridyl)benzimidazole ligand (L) in RhCl(η-CMe)L gives rise to a water-soluble complex, which can bind to the model protein lysozyme via non-covalent interactions. The complex shows selective moderate toxicity against Cryptococcus neoformans (MIC = 21.6-43.3 μM) and exhibits no cytotoxicity to healthy HEK293 cells.
在RhCl(η-CMe)L中，将丙磺酸基团引入到配位的2-(2-吡啶基)苯并咪唑配体(L)的N1位置，得到一种水溶性配合物，该配合物可通过非共价相互作用与模型蛋白溶菌酶结合。该配合物对新型隐球菌显示出选择性中度毒性(MIC = 21.6 - 43.3 μM)，对健康的HEK293细胞无细胞毒性。
