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A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease.甘特纳单抗或 Solanezumab 治疗显性遗传性阿尔茨海默病的临床试验。
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2
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Nature. 2021 Jun;594(7863):309-310. doi: 10.1038/d41586-021-01546-2.
3
Alzheimer's disease drug development pipeline: 2021.2021年阿尔茨海默病药物研发进展
Alzheimers Dement (N Y). 2021 May 25;7(1):e12179. doi: 10.1002/trc2.12179. eCollection 2021.
4
The need to show minimum clinically important differences in Alzheimer's disease trials.在阿尔茨海默病临床试验中需要显示最小临床重要差异。
Lancet Psychiatry. 2021 Nov;8(11):1013-1016. doi: 10.1016/S2215-0366(21)00197-8. Epub 2021 Jun 1.
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Alzheimers Res Ther. 2021 Apr 17;13(1):80. doi: 10.1186/s13195-021-00813-8.
6
Evaluation of Aducanumab for Alzheimer Disease: Scientific Evidence and Regulatory Review Involving Efficacy, Safety, and Futility.阿杜卡努单抗治疗阿尔茨海默病的评估:涉及疗效、安全性和无效性的科学证据与监管审查
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Donanemab in Early Alzheimer's Disease.多奈单抗用于早期阿尔茨海默病
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8
Alzheimer's disease.阿尔茨海默病。
Lancet. 2021 Apr 24;397(10284):1577-1590. doi: 10.1016/S0140-6736(20)32205-4. Epub 2021 Mar 2.
9
Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer's disease: a PET substudy interim analysis.甘特纳珠单抗可减少前驱期至中度阿尔茨海默病患者的淀粉样蛋白-β斑块:一项 PET 亚研究中期分析。
Alzheimers Res Ther. 2019 Dec 12;11(1):101. doi: 10.1186/s13195-019-0559-z.
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The "rights" of precision drug development for Alzheimer's disease.阿尔茨海默病精准药物研发的“权利”。
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阿杜卡奴单抗:阿尔茨海默病治疗开发的新阶段?

Aducanumab: a new phase in therapeutic development for Alzheimer's disease?

机构信息

UK Dementia Research Institute at UCL, London, UK.

Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.

出版信息

EMBO Mol Med. 2021 Aug 9;13(8):e14781. doi: 10.15252/emmm.202114781. Epub 2021 Aug 2.

DOI:10.15252/emmm.202114781
PMID:34338436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8350893/
Abstract

On 7 June the FDA approved aducanumab, the first new drug for Alzheimer's disease in almost 20 years-and notably, the first drug with a putative disease-modifying mechanism for the treatment of this devastating disorder, namely the removal of β-amyloid (or Aβ) plaques from the brain.

摘要

6 月 7 日,FDA 批准了 aducanumab,这是近 20 年来首款用于治疗阿尔茨海默病的新药——值得注意的是,这也是首款具有潜在疾病修饰机制的治疗这种破坏性疾病的药物,即从大脑中清除β-淀粉样蛋白(或 Aβ)斑块。