Luo Yanzhu, Yang Wanju, Qi Mengying, Wang Yuhong, Li Shaowei, Wang Mingwu, Zeng Qingyan
Aier Eye Hospital, Wuhan University, Wuhan, Hubei Province, China.
Department of Cornea & Ocular Surface Diseases, Wuhan Aier Hankou Eye Hospital, Wuhan, Hubei Province, China.
Ophthalmic Epidemiol. 2023 Apr;30(2):121-128. doi: 10.1080/09286586.2021.1959618. Epub 2021 Aug 2.
To study the direct economic burden of dry eye diseases (DED) on Chinese residents and analyze the influencing factors of the direct economic burden of patients with DED.
Two hundred and twenty-one Chinese adults with DED who underwent treatment in Wuhan Aier Hankou Eye Hospital were enrolled in this health economics research from January 2018 to August 2018 and followed for at least 1 year. Examination, pharmacological therapy, and nonpharmacological therapy costs were collected to calculate the annual direct economic burden of DED on patients through the outpatient medical record system.
Annual direct economic burden caused by DED on each patient was $465.54 ± 303.08. The direct economic burden of female patients in the 40-49 years group was significantly higher than that of male patients ( < .05). Age, number of hospital visits and severity of DED were showed a significant influence on the direct economic burden both in univariate linear regression analysis and multiple linear regression analysis. Subtype of DED was showed a significant influence on the direct economic burden in multiple linear regression analysis after eliminating confounding factors.
This study preliminarily analyzed the direct economic burden of Chinese DED patients. Age, number of hospital visits, severity of DED, mixed and evaporative dry eye (EDE) subtypes are shown to be the significant influencing factors of the direct economic burden and sex is a potential influencing factor.
研究干眼疾病（DED）对中国居民的直接经济负担，并分析DED患者直接经济负担的影响因素。
选取2018年1月至2018年8月在武汉爱尔汉口眼科医院接受治疗的221例成年DED患者纳入本卫生经济学研究，并随访至少1年。通过门诊病历系统收集检查、药物治疗和非药物治疗费用，以计算DED对患者的年度直接经济负担。
DED对每位患者造成的年度直接经济负担为465.54美元±303.08美元。40 - 49岁组女性患者的直接经济负担显著高于男性患者（P <.05）。在单因素线性回归分析和多因素线性回归分析中，年龄、就诊次数和DED严重程度均对直接经济负担有显著影响。在消除混杂因素后的多因素线性回归分析中，DED亚型对直接经济负担有显著影响。
本研究初步分析了中国DED患者的直接经济负担。年龄、就诊次数、DED严重程度、混合型和蒸发型干眼（EDE）亚型是直接经济负担的显著影响因素，性别是潜在影响因素。
