School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil.
Nutr Rev. 2022 Apr 8;80(5):1086-1093. doi: 10.1093/nutrit/nuab054.
Zinc supplementation is indicated for diarrhea and taste disorders, which are both features of COVID-19 . Nevertheless, this strategy has not been tested for the treatment of these secondary complications in the current pandemic. Through an updated review, a practical appraisal was considered as a means of providing a medical nexus of therapeutic zinc regimens as an adjunct in the management of COVID-19-related diarrhea and ageusia/dysgeusia. While diarrhea and taste disorders are consequences of COVID-19, zinc supplementation is useful for non-COVID-19 patients with these clinical problems. The overwhelming evidence for supplementing with zinc in diarrhea and pneumonia is associated with the treatment of children, while for taste disorders the use of supplementing with zinc is more examined in adults. Whereas COVID-19 is more prevalent in adults, precautions should be exercised not to translate the zinc dosage used for children with diarrhea and taste disorders into the current pandemic. Therapeutic doses of zinc used for adults (∼50-150 mg/day of elemental zinc) could be included in the treatment strategies for COVID-19, but this proposal should be examined through randomized studies.
锌补充剂适用于腹泻和味觉障碍，这两者都是 COVID-19 的特征。然而，在当前的大流行中，尚未针对这些继发性并发症的治疗对该策略进行测试。通过更新的综述，将实际评估视为提供治疗性锌方案的医学联系的一种手段，作为 COVID-19 相关腹泻和味觉丧失/味觉障碍管理的辅助手段。虽然腹泻和味觉障碍是 COVID-19 的后果，但锌补充剂对患有这些临床问题的非 COVID-19 患者有用。在腹泻和肺炎中补充锌的压倒性证据与儿童的治疗有关，而对于味觉障碍，补充锌的使用在成年人中得到了更多的研究。由于 COVID-19 在成年人中更为普遍，因此应谨慎行事，不要将用于腹泻和味觉障碍儿童的锌剂量转化为当前的大流行。用于成年人的治疗剂量的锌（每天约 50-150mg 元素锌）可以纳入 COVID-19 的治疗策略中，但应通过随机研究来检验这一建议。
