Henkin R I, Schecter P J, Friedewald W T, Demets D L, Raff M
Am J Med Sci. 1976 Nov-Dec;272(3):285-99. doi: 10.1097/00000441-197611000-00006.
A randomized, double blind crossover study of the effects of zinc sulfate and placebo was carried out in 106 patients with taste and smell dysfunction secondary to a variety of etiological factors. In the patient group prior to treatment, mean serum zinc concentration and leukocyte alkaline phosphatase activity were significantly lower than normal. Results indicate that zinc sulfate was effectively equivalent to placebo in the treatment of these disorders. Although these results demonstrate abnormalities of zinc metabolism in some patients with taste and smell dysfunction they fail to provide evidence for a single, therapeutic approach to the many disorders which are associated with abnormalities of taste and smell. However, the methods and procedures developed in this study demonstrate that taste and smell dysfunction can be studied in a quantitative, systematic manner.
对106例因多种病因导致味觉和嗅觉功能障碍的患者进行了一项关于硫酸锌和安慰剂效果的随机双盲交叉研究。在治疗前的患者组中，血清锌平均浓度和白细胞碱性磷酸酶活性显著低于正常水平。结果表明，硫酸锌在治疗这些疾病方面与安慰剂效果相当。尽管这些结果表明一些味觉和嗅觉功能障碍患者存在锌代谢异常，但它们未能为与味觉和嗅觉异常相关的多种疾病提供单一的治疗方法的证据。然而，本研究中开发的方法和程序表明，可以以定量、系统的方式研究味觉和嗅觉功能障碍。
