Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China.
HMU-UCCSM Centre for Infection and Genomics, Harbin, China.
Adv Exp Med Biol. 2021;1330:55-73. doi: 10.1007/978-3-030-73359-9_4.
Ovarian cancer, one of the three leading malignancies in women, has high incidence and mortality worldwide. It is hard to diagnose until very late stages and the 5-year survival rate is very low, due mostly to its distant metastasis. Chemotherapy is currently the most common treatment to inhibit cancer growth, but long-term use could result in resistance and tumor recurrence in addition to damages to normal tissues and functions of the patients. In order to achieve safe and curative effects against cancers, many investigators have focused their attention on traditional Chinese herbal medicines. Paclitaxel, a natural antitumor agent, has significant effects on advanced malignancies including ovarian cancer and is in the standard front-line treatment. Additional natural anticancer substances have continually been discovered for their high effectiveness and low side-effects in ovarian cancer prevention and therapy. In this chapter, we summarize recent work on a selected group of natural components, including lignans, ellagic acid, luteolin, mangiferin, and Acanthopanax senticosus, which have all been demonstrated to reduce the progress of epithelial ovarian cancer in a dose-depend manner, by both in vitro and in vivo experiments. The mechanisms of the anticancer activities by these natural components involve expression suppression of MMP2 and MMP9.
卵巢癌是女性三大恶性肿瘤之一，全球发病率和死亡率都很高。由于其远处转移，直到晚期才被诊断出来，5 年生存率非常低。化疗是目前抑制肿瘤生长最常用的治疗方法，但长期使用不仅会导致耐药性和肿瘤复发，还会损害患者的正常组织和功能。为了实现安全有效的癌症治疗效果，许多研究人员将注意力集中在中药上。紫杉醇是一种天然抗肿瘤药物，对包括卵巢癌在内的晚期恶性肿瘤有显著疗效，是标准的一线治疗药物。在卵巢癌的预防和治疗中，人们不断发现具有高效低副作用的天然抗癌物质。在本章中，我们总结了最近一组天然成分的研究工作，包括木脂素、鞣花酸、木樨草素、芒果苷和刺五加，这些成分在体外和体内实验中都被证明能以剂量依赖的方式减缓上皮性卵巢癌的进展。这些天然成分的抗癌活性机制涉及 MMP2 和 MMP9 的表达抑制。
