Clinical Ergospirometry, Exercise and Rehabilitation Laboratory, National and Kapodistrian University of Athens, Athens, Greece.
1(st) Department of Pathology, National and Kapodistrian University of Athens, Athens, Greece.
Int J Cardiol. 2021 Oct 15;341:88-95. doi: 10.1016/j.ijcard.2021.07.055. Epub 2021 Jul 30.
Acute exercise and exercise training may confer epigenetic modifications in healthy subjects. Epigenetic effects after exercise have been showed in patients with cardiovascular disease. The aim of this systematic review was to summarize the evidence from available clinical trials that study epigenetic adaptations after exercise in patients with cardiovascular disease.
The search strategy was performed in PubMed and CENTRAL databases on articles published until September 2020. Studies with titles and abstracts relevant to exercise epigenetic modification applied to cardiovascular patients were fully examined. Inclusion and exclusion criteria were utilized for studies screening. Quality assessment with PEDro scale and evaluation by two independent reviewers was performed.
Of the 1714 articles retrieved, 88 articles were assessed for eligibility criteria and 8 articles matched our search criteria and finally included in the systematic analysis. The acute exercise epigenetic (miRNAs) effects were assessed in three studies and the chronic exercise training effects (miRNAs and DNA methylation) in six studies. The results have shown that there is possibly an acute significant exercise effect on epigenetic targets which is more evident after chronic exercise training.
By the present systematic review, we provide preliminary evidence of beneficial epigenetic adaptations following acute and chronic exercise in patients with cardiovascular disease. More controlled studies are needed to confirm such evidence.
急性运动和运动训练可能会使健康受试者产生表观遗传修饰。运动后的表观遗传效应已在心血管疾病患者中得到证实。本系统评价的目的是总结目前已发表的临床试验证据，这些试验研究了心血管疾病患者运动后的表观遗传适应。
在 PubMed 和 CENTRAL 数据库中进行了搜索策略，检索截至 2020 年 9 月的文章。对标题和摘要与心血管患者应用运动表观遗传修饰相关的文章进行了全面检查。使用 PEDro 量表进行纳入和排除标准筛选，并由两名独立评审员进行质量评估。
在检索到的 1714 篇文章中，有 88 篇文章符合入选标准，8 篇文章符合我们的检索标准，最终纳入系统分析。有三项研究评估了急性运动的表观遗传（miRNA）效应，六项研究评估了慢性运动训练的效应（miRNA 和 DNA 甲基化）。结果表明，急性运动可能对表观遗传靶标产生显著影响，而慢性运动训练后的影响更为明显。
通过本系统评价，我们初步提供了心血管疾病患者急性和慢性运动后有益的表观遗传适应证据。需要更多的对照研究来证实这一证据。
