Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States; Department of Psychology, University of Minnesota, Minneapolis, MN, United State.
Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States.
Neuroimage. 2021 Nov 1;241:118439. doi: 10.1016/j.neuroimage.2021.118439. Epub 2021 Jul 30.
Investigations within the Human Connectome Project have expanded to include studies focusing on brain disorders. This paper describes one of the investigations focused on psychotic psychopathology: The psychosis Human Connectome Project (P-HCP). The data collected as part of this project were multimodal and derived from clinical assessments of psychopathology, cognitive assessments, instrument-based motor assessments, blood specimens, and magnetic resonance imaging (MRI) data. The dataset will be made publicly available through the NIMH Data Archive. In this report we provide specific information on how the sample of participants was obtained and characterized and describe the experimental tasks and procedures used to probe neural functions involved in psychotic disorders that may also mark genetic liability for psychotic psychopathology. Our goal in this paper is to outline the data acquisition process so that researchers intending to use these publicly available data can plan their analyses. MRI data described in this paper are limited to data acquired at 3 Tesla. A companion paper describes the study's 7 Tesla image acquisition protocol in detail, which is focused on visual perceptual functions in psychotic psychopathology.
人类连接组计划的研究已经扩展到包括专注于大脑疾病的研究。本文描述了其中一项专注于精神病病理学的研究：精神病人类连接组计划（P-HCP）。该项目收集的数据是多模态的，来自精神病理学的临床评估、认知评估、基于仪器的运动评估、血液样本和磁共振成像（MRI）数据。该数据集将通过 NIMH 数据档案公开提供。在本报告中，我们提供了关于如何获得和描述参与者样本的具体信息，并描述了用于探测涉及精神病的神经功能的实验任务和程序，这些功能也可能标志着精神病病理学的遗传易感性。我们在本文中的目标是概述数据采集过程，以便有意使用这些公开可用数据的研究人员可以计划他们的分析。本文描述的 MRI 数据仅限于在 3 特斯拉下获得的数据。一篇配套论文详细描述了该研究的 7 特斯拉图像采集协议，该协议专注于精神病病理学中的视觉感知功能。
