Kutsenko S A
Farmakol Toksikol. 1976 Jan-Feb;39(1):35-9.
Experiments in vitro demonstrated that a thermostatic treatment of an aqueous chlorophos solution at 38 degrees is attended by its increased cholinesterase activity. The speed of the process is much higher in an alkaline medium. A joint incubation of chlorophos with the TMB-4 reactivator of pH of 7.5 and 38 degrees not only fails to result in decomposition of the poison, but on the contrary, tends to speed up the progressive accretion of the inhibitory properties of this organophosphorus compound. The author considers the data obtained as one of the proofs pointing to the formation during direct interaction of TMB-4 with chlorophos or the product of its transformation of a stable complex appearing to be a powerful anticholinesterase agent.
体外实验表明，对水溶液中的毒死蜱在38℃进行恒温处理时，其胆碱酯酶活性会增强。该过程在碱性介质中的速度要快得多。将毒死蜱与pH值为7.5且温度为38℃的TMB - 4复活剂共同孵育，不仅不会导致毒物分解，相反，往往会加速这种有机磷化合物抑制特性的逐渐增强。作者认为所获得的数据是指向TMB - 4与毒死蜱直接相互作用过程中形成或其转化产物形成一种稳定复合物的证据之一，这种复合物似乎是一种强大的抗胆碱酯酶剂。
