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一个基因的同源物参与了 对小麦秆锈病的非寄主抗性。

A Homolog of the Gene Is Involved in Nonhost Resistance to Wheat Stem Rust in .

机构信息

Department of Agronomy and Plant Genetics, University of Minnesota, St. Paul, MN 55108, U.S.A.

CAPES Foundation, Ministry of Education of Brazil, Brasilia, DF, Brazil.

出版信息

Mol Plant Microbe Interact. 2021 Nov;34(11):1298-1306. doi: 10.1094/MPMI-06-21-0137-R. Epub 2021 Nov 16.

Abstract

Plants resist infection by pathogens using both preexisting barriers and inducible defense responses. Inducible responses are governed in a complex manner by various hormone signaling pathways. The relative contribution of hormone signaling pathways to nonhost resistance to pathogens is not well understood. In this study, we examined the molecular basis of disrupted nonhost resistance to the fungal species , which causes stem rust of wheat, in an induced mutant of the model grass . Through bioinformatic analysis, a 1-bp deletion in the mutant genotype was identified that introduces a premature stop codon in the gene , which is a homolog of the gene (). In , is central to the regulation of the circadian clock and plays a crucial role in jasmonate signaling by attenuating levels of the transcription factor protein MYC2, and its mutational disruption results in enhanced susceptibility to the hemibiotroph . Our similar finding for an obligate biotroph suggests that the biochemical role of in mediating disease resistance to biotrophs is conserved in grasses, and that the correct modulation of jasmonate signaling during infection by may be essential for nonhost resistance to wheat stem rust in .[Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY 4.0 International license.

摘要

植物利用先天存在的障碍和可诱导的防御反应来抵抗病原体的感染。诱导性反应是由各种激素信号通路以复杂的方式控制的。激素信号通路对非寄主植物抵抗病原体的相对贡献还不太清楚。在这项研究中,我们通过生物信息学分析,研究了模式草突变体中导致小麦茎锈病的真菌种非寄主抗性破坏的分子基础。在突变体基因型中发现了 1 个碱基对缺失,导致基因()中引入了一个提前终止密码子。在拟南芥中,是生物钟调控的核心,通过削弱转录因子蛋白 MYC2 的水平,在茉莉酸信号转导中发挥关键作用,其突变破坏导致对半活体的易感性增强。我们在专性活体中也有类似的发现,这表明在介导对活体的抗病性方面,中茉莉酸信号转导的生化作用在禾本科植物中是保守的,并且在活体侵染过程中正确调节茉莉酸信号可能对小麦茎锈病的非寄主抗性至关重要。[公式: 见正文]

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