Department of Anthropology, Yale University, New Haven, CT, USA.
Yale School of Medicine, Yale University, New Haven, CT, USA.
Ann Hum Biol. 2021 Jun;48(4):346-349. doi: 10.1080/03014460.2021.1951351. Epub 2021 Aug 3.
The " (Beginning of Life)" study is a prospective birth cohort of = 160 Samoan mother-infant dyads established in 2017-2018. A primary study aim is to explore how a missense variant at rs373863828 impacts growth in early life, given its association with increased body size but lower risk of diabetes in adult Samoans. Here, we examine body size and composition by genotype among toddlers aged 18.7-24.5 months.
Height, weight, head circumference, mid-upper-arm circumference, and abdominal circumference, as well as subscapular, triceps, iliac crest and thigh skinfold thickness were measured among 107 toddlers with known rs373863828 genotype; 42 of these toddlers completed dual-energy X-ray absorptiometry (DXA) scans from which body composition (total body less head fat mass, lean mass, bone mass, % fat mass and % fat-free mass) was estimated.
After controlling for sex and age, toddlers with at least one copy of the minor allele (AA/AG) were 1.31 cm taller (SE = 0.64, = 0.045) than toddlers with the GG genotype.
Whether greater linear growth in early childhood could contribute to the metabolically protective effects associated with the variant in adulthood should be explored in future studies.
“（生命伊始）”研究是一项前瞻性的萨摩亚母婴队列研究，纳入了 160 对母婴。该研究的主要目的是探索 rs373863828 错义变异如何影响生命早期的生长，因为该变异与成人萨摩亚人群的体型增大但糖尿病风险降低有关。在此，我们根据基因型检查了 18.7-24.5 月龄幼儿的体型和组成。
对 107 名已知 rs373863828 基因型的幼儿进行身高、体重、头围、中上臂围、腹围以及肩胛下、肱三头肌、髂嵴和大腿皮褶厚度测量；其中 42 名幼儿完成了双能 X 射线吸收法（DXA）扫描，可据此估计身体组成（全身除头部的脂肪质量、瘦体重、骨量、脂肪质量百分比和无脂肪质量百分比）。
在控制性别和年龄后，至少携带一个 minor allele（AA/AG）的幼儿比 GG 基因型的幼儿高 1.31cm（SE=0.64，=0.045）。
在未来的研究中，应该探索儿童早期线性生长增加是否有助于解释与该变异相关的成年期代谢保护作用。
