State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.
Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Tianjin, 300020, China.
Sci China Life Sci. 2021 Dec;64(12):2030-2044. doi: 10.1007/s11427-021-1961-1. Epub 2021 Jul 30.
Since the huge success of bone marrow transplantation technology in clinical practice, hematopoietic stem cells (HSCs) have become the gold standard for defining the properties of adult stem cells (ASCs). Here, we describe the "self-renewal, multi-lineage differentiation, apoptosis, rest, and trafficking" or "SMART" model, which has been developed based on data derived from studies of HSCs as the most well-characterized stem cell type. Given the potential therapeutic applications of ASCs, we delineate the key characteristics of HSCs using this model and speculate on the physiological relevance of stem cells identified in other tissues. Great strides are being made in understanding the biology of ASCs, and efforts are now underway to develop safe and effective ASC-based therapies in this emerging area.
自骨髓移植技术在临床实践中取得巨大成功以来，造血干细胞（HSCs）已成为定义成人干细胞（ASCs）特性的金标准。在这里，我们描述了“自我更新、多系分化、凋亡、静止和运输”或“SMART”模型，该模型是基于对作为最典型的干细胞类型的 HSCs 的研究数据而开发的。鉴于 ASCs 的潜在治疗应用，我们使用该模型描绘 HSCs 的关键特征，并推测其他组织中鉴定的干细胞的生理相关性。目前，人们在理解 ASCs 的生物学方面取得了重大进展，目前正在努力在这一新兴领域开发安全有效的基于 ASC 的疗法。
