Animal Physiology and Reproduction Division, ICAR-Central Institute for Research on Buffaloes, Hisar-125001, Haryana, India.
Curr Stem Cell Res Ther. 2022;17(3):252-266. doi: 10.2174/1574888X16666210803162019.
Pluripotent stem cells (PSCs) have unlimited capacity for self-renewal and differentiation so that they can potentially produce any cell or tissue of animal's body. The PSCs derived from livestock represents a more appropriate model than a rodent for investigating human diseases due to their higher anatomical and physiological resemblance with human. Apart from that, livestock PSCs hold immense promises for innovative therapies, transgenic animal production and their biomedical interest. The realization of the full potential of PSCs, however, depends on the elucidation of the molecular mechanisms which play a critical role in the maintenance of pluripotency and reprogramming procedure remains poorly understood in livestock which in turn impedes the generation of true PSCs and their usage for clinical research. An in-depth understanding of pluripotency is extremely essential for improving health and welfare of livestock animals. Therefore, the present review focuses on the milestone achievements of PSCs in livestock animals and their potential application in health and production of livestock.
多能干细胞（PSCs）具有无限的自我更新和分化能力，因此它们可以潜在地产生动物体的任何细胞或组织。源自家畜的 PSCs 比啮齿动物更适合用于研究人类疾病，因为它们在解剖学和生理学上与人类更为相似。除此之外，家畜 PSCs 在创新疗法、转基因动物生产及其生物医学方面具有巨大的应用前景。然而，要实现 PSCs 的全部潜力，取决于阐明在维持多能性和重编程过程中发挥关键作用的分子机制，而家畜在这方面的理解还很不完善，这反过来又阻碍了真正的 PSCs 的产生及其在临床研究中的应用。深入了解多能性对于改善家畜的健康和福利至关重要。因此，本综述重点介绍了家畜 PSCs 的里程碑式成就及其在家畜健康和生产中的潜在应用。
