Yale Cardiovascular Research Center, Departments of Internal Medicine and Cell Biology, Yale University School of Medicine, New Haven, CT 06511, USA.
Sci Signal. 2021 Aug 3;14(694):eabc6612. doi: 10.1126/scisignal.abc6612.
Phospholipase C γ1 (PLCγ1) is a member of the PLC family that functions as signal transducer by hydrolyzing membrane lipid to generate second messengers. The unique protein structure of PLCγ1 confers a critical role as a direct effector of VEGFR2 and signaling mediated by other receptor tyrosine kinases. The distinct vascular phenotypes in PLCγ1-deficient animal models and the gain-of-function mutations of PLCγ1 found in human endothelial cancers point to a major physiological role of PLCγ1 in the endothelial system. In this review, we discuss aspects of physiological and molecular function centering around PLCγ1 in the context of endothelial cells and provide a perspective for future investigation.
磷酯酶 C γ1（PLCγ1）是 PLC 家族的一员，通过水解膜脂质生成第二信使，作为信号转导物发挥作用。PLCγ1 的独特蛋白质结构赋予其作为 VEGFR2 的直接效应物以及其他受体酪氨酸激酶介导的信号转导的关键作用。PLCγ1 缺陷动物模型中的独特血管表型和人类内皮癌细胞中发现的 PLCγ1 功能获得性突变，表明 PLCγ1 在血管内皮系统中具有重要的生理作用。在这篇综述中，我们围绕 PLCγ1 在血管内皮细胞中的生理和分子功能进行讨论，并为未来的研究提供了一个视角。
