肿瘤抑制因子RBM24抑制肝癌细胞中CTNNB1的核转位和TP63的表达。

Moon Sung Ung, Kim Jang Hyun, Woo Hyun Goo

Department of Physiology, Ajou University School of Medicine, Suwon, Gyeonggi 16499, Republic of Korea.

Department of Biomedical Science, Graduate School, Ajou University, Suwon, Gyeonggi 16499, Republic of Korea.

Oncol Lett. 2021 Sep;22(3):674. doi: 10.3892/ol.2021.12935. Epub 2021 Jul 19.

RNA-binding protein 24 (RBM24) has been shown to play tumor-suppressive functions in various types of cancer. The present study aimed to investigate the role of RBM24 in liver cancers and its downstream mechanisms. The present study demonstrated that RBM24 functioned as a tumor suppressor in liver cancer cells, and inhibited nuclear translocation of β-catenin and tumor protein 63 expression by immunocytochemistry. In addition, RBM24 could suppress sphere formation in a multicellular tumor spheroid model of liver cancer cells. In conclusion, it is hypothesized that RBM24 is a tumor suppressor of liver cancer cells, which could be a potential novel therapeutic target for treatment of patients with liver cancer.

RNA结合蛋白24（RBM24）已被证明在多种癌症中发挥肿瘤抑制功能。本研究旨在探讨RBM24在肝癌中的作用及其下游机制。本研究表明，RBM24在肝癌细胞中起肿瘤抑制作用，并通过免疫细胞化学抑制β-连环蛋白的核转位和肿瘤蛋白63的表达。此外，RBM24可以在肝癌细胞的多细胞肿瘤球体模型中抑制球体形成。总之，据推测RBM24是肝癌细胞的肿瘤抑制因子，这可能是治疗肝癌患者的潜在新治疗靶点。