• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

甲状旁腺功能减退继发 Fahr 综合征的一种独特表现。

A Unique Presentation of Fahr's Syndrome Secondary to Hypoparathyroidism.

作者信息

Rashid Khan Zaraq, Waheed Waqar, Mabood Jawad, Ali Asim, Burki Gulalai

机构信息

Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK.

Internal Medicine, Mufti Mehmood Memorial Teaching Hospital, Dera Ismail Khan, PAK.

出版信息

Cureus. 2021 Jun 30;13(6):e16063. doi: 10.7759/cureus.16063. eCollection 2021 Jun.

DOI:10.7759/cureus.16063
PMID:34345548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8323617/
Abstract

Fahr's syndrome is a rare condition characterized by deposition of bilateral symmetric calcium deposits in the basal ganglia and cerebellar region, leading to neurological and psychiatric sequelae. Herein we describe a case of a 62-year-old female presented with aphasia, bilateral lower limb rigidity, tremors, and gait disturbance. Her past medical history included thyroidectomy and radiation therapy 10 years back due to papillary carcinoma of the thyroid gland. On examination, she had poor speech, resting tremor, walking difficulty, and decreased power in all limbs with rigidity. Her Chvostek and Trousseau signs were positive. Serum investigations revealed hypocalcemia and low levels of parathyroid hormone and thyroid-stimulating hormone. Brain magnetic resonance imaging revealed calcified lesions in basal ganglia, thalami, and dentate nuclei. She was diagnosed with Fahr's syndrome due to hypoparathyroidism, and she was managed with calcium gluconate, vitamin D, salt-free albumin, and levodopa-carbidopa, improving her condition. The patient was then discharged on calcium gluconate, calcitriol, recombinant parathyroid hormone, and levodopa-carbidopa with follow-up.

摘要

法尔氏综合征是一种罕见病症,其特征为双侧对称的钙沉积于基底神经节和小脑区域,从而导致神经和精神方面的后遗症。在此,我们描述一例62岁女性病例,该患者出现失语、双侧下肢僵硬、震颤及步态障碍。她的既往病史包括10年前因甲状腺乳头状癌接受甲状腺切除术及放射治疗。检查时,她存在言语不清、静止性震颤、行走困难,且四肢肌力下降伴僵硬。她的Chvostek征和Trousseau征呈阳性。血清检查显示低钙血症以及甲状旁腺激素和促甲状腺激素水平低下。脑部磁共振成像显示基底神经节、丘脑和齿状核有钙化病变。她因甲状旁腺功能减退被诊断为法尔氏综合征,并接受葡萄糖酸钙、维生素D、无盐白蛋白和左旋多巴 - 卡比多巴治疗,病情有所改善。随后患者出院时带药葡萄糖酸钙、骨化三醇、重组甲状旁腺激素和左旋多巴 - 卡比多巴,并进行随访。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff00/8323617/1e8bd6b945cd/cureus-0013-00000016063-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff00/8323617/9022342ac129/cureus-0013-00000016063-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff00/8323617/1e8bd6b945cd/cureus-0013-00000016063-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff00/8323617/9022342ac129/cureus-0013-00000016063-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff00/8323617/1e8bd6b945cd/cureus-0013-00000016063-i02.jpg

相似文献

1
A Unique Presentation of Fahr's Syndrome Secondary to Hypoparathyroidism.甲状旁腺功能减退继发 Fahr 综合征的一种独特表现。
Cureus. 2021 Jun 30;13(6):e16063. doi: 10.7759/cureus.16063. eCollection 2021 Jun.
2
Fahr's syndrome with hypoparathyroidism, thrombocytopenia, and seizure: a rare case report.伴有甲状旁腺功能减退、血小板减少症和癫痫发作的法尔综合征:一例罕见病例报告
Ann Med Surg (Lond). 2023 Jun 28;85(8):4131-4133. doi: 10.1097/MS9.0000000000001032. eCollection 2023 Aug.
3
[Psychotic disorder induced by Fahr's syndrome: a case report].[法尔氏综合征所致精神障碍:一例报告]
Encephale. 2014 Jun;40(3):271-5. doi: 10.1016/j.encep.2013.04.012. Epub 2013 Jun 28.
4
Fahr's Syndrome Secondary to Primary Hypoparathyroidism Presenting With Seizures and the Role of Steroid Therapy.原发性甲状旁腺功能减退继发 Fahr 综合征伴癫痫发作及类固醇治疗的作用
Clin Med Insights Case Rep. 2023 May 28;16:11795476231178119. doi: 10.1177/11795476231178119. eCollection 2023.
5
Hypoparathyroidism with Fahr's syndrome: A case report and review of the literature.甲状旁腺功能减退症合并法尔综合征:一例报告及文献复习
World J Clin Cases. 2019 Nov 6;7(21):3662-3670. doi: 10.12998/wjcc.v7.i21.3662.
6
A Case of Seizure Revealing Fahr's Syndrome with Primary Hypoparathyroidism.一例以癫痫发作起病并伴有原发性甲状旁腺功能减退的法尔氏综合征病例。
Am J Case Rep. 2018 Dec 1;19:1430-1433. doi: 10.12659/AJCR.913382.
7
Concomitant Fahr's syndrome and thoracic ossification of the posterior longitudinal ligament caused by idiopathic hypoparathyroidism - case report.特发性甲状旁腺功能减退症引起的并发 Fahr 综合征和胸段后纵韧带骨化 - 病例报告。
BMC Musculoskelet Disord. 2019 Aug 7;20(1):362. doi: 10.1186/s12891-019-2747-1.
8
A Rare Case of Fahr's Syndrome in a Patient with Secondary Hypoparathyroidism and Neuropsychiatric Symptoms.一例继发甲状旁腺功能减退并伴有神经精神症状患者的法尔综合征罕见病例。
Innov Clin Neurosci. 2021 Apr-Jun;18(4-6):11-14.
9
Secondary Fahr's Disease: A Consequence of Post-Thyroidectomy Hypoparathyroidism.继发性法尔氏病:甲状腺切除术后甲状旁腺功能减退的后果。
Eur J Case Rep Intern Med. 2019 Jun 4;6(6):001109. doi: 10.12890/2019_001109. eCollection 2019.
10
Ischemic stroke in a young patient with Fahr's disease: a case report.法尔氏病年轻患者的缺血性中风:一例报告。
BMC Neurol. 2016 Mar 8;16:33. doi: 10.1186/s12883-016-0557-8.

引用本文的文献

1
A Rare Presentation of Fahr's Syndrome Associated With Secondary Hyperparathyroidism.与继发性甲状旁腺功能亢进相关的法尔综合征的罕见表现。
Clin Case Rep. 2025 Jan 19;13(1):e70134. doi: 10.1002/ccr3.70134. eCollection 2025 Jan.
2
Fahr's Syndrome Secondary to Primary Hypoparathyroidism Presenting With Seizures and the Role of Steroid Therapy.原发性甲状旁腺功能减退继发 Fahr 综合征伴癫痫发作及类固醇治疗的作用
Clin Med Insights Case Rep. 2023 May 28;16:11795476231178119. doi: 10.1177/11795476231178119. eCollection 2023.
3
Fahr's Syndrome Presenting With Hypocalcemia and Psychotic Features.

本文引用的文献

1
Hypoparathyroidism with Fahr's syndrome: A case report and review of the literature.甲状旁腺功能减退症合并法尔综合征:一例报告及文献复习
World J Clin Cases. 2019 Nov 6;7(21):3662-3670. doi: 10.12998/wjcc.v7.i21.3662.
2
Secondary Fahr's Disease: A Consequence of Post-Thyroidectomy Hypoparathyroidism.继发性法尔氏病:甲状腺切除术后甲状旁腺功能减退的后果。
Eur J Case Rep Intern Med. 2019 Jun 4;6(6):001109. doi: 10.12890/2019_001109. eCollection 2019.
3
Fahr's syndrome.法尔综合征。
Fahr综合征伴低钙血症及精神病性症状表现
Cureus. 2021 Sep 19;13(9):e18091. doi: 10.7759/cureus.18091. eCollection 2021 Sep.
Intern Emerg Med. 2019 Apr;14(3):483-484. doi: 10.1007/s11739-018-1998-4. Epub 2018 Nov 30.
4
Fahr's syndrome and clinical correlation: a case series and literature review.法尔综合征及其临床关联:病例系列报告与文献综述
Folia Neuropathol. 2016;54(3):282-294. doi: 10.5114/fn.2016.62538.
5
Fahr's Disease or Fahr's Syndrome?法尔氏病还是法尔氏综合征?
Innov Clin Neurosci. 2016 Aug 1;13(7-8):45-6. eCollection 2016 Jul-Aug.
6
Fahr's syndrome.法尔综合征。
Rev Clin Esp (Barc). 2016 Oct;216(7):400-401. doi: 10.1016/j.rce.2016.03.002. Epub 2016 Apr 14.
7
Fahr's syndrome: literature review of current evidence. Fahr 综合征:当前证据的文献综述。
Orphanet J Rare Dis. 2013 Oct 8;8:156. doi: 10.1186/1750-1172-8-156.
8
Phenotypic spectrum of probable and genetically-confirmed idiopathic basal ganglia calcification.可能的和基因证实的特发性基底节钙化的表型谱。
Brain. 2013 Nov;136(Pt 11):3395-407. doi: 10.1093/brain/awt255. Epub 2013 Sep 24.
9
Fahr's Syndrome- An Interesting Case Presentation.法尔综合征——一例有趣的病例报告。
J Clin Diagn Res. 2013 Mar;7(3):532-3. doi: 10.7860/JCDR/2013/4946.2814. Epub 2013 Mar 1.
10
Neuropsychiatric correlates and treatment of lenticulostriatal diseases: a review of the literature and overview of research opportunities in Huntington's, Wilson's, and Fahr's diseases. A report of the ANPA Committee on Research. American Neuropsychiatric Association.豆状核纹状体疾病的神经精神关联与治疗:亨廷顿病、威尔逊病和法尔病的文献综述及研究机会概述。美国神经精神协会研究委员会报告。美国神经精神协会
J Neuropsychiatry Clin Neurosci. 1998 Summer;10(3):249-66. doi: 10.1176/jnp.10.3.249.