Anggani Haru Setyo, Arifiani Putri, Siregar Erwin
Department of Orthodontic, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia.
J Adv Pharm Technol Res. 2021 Jul-Sep;12(3):274-278. doi: 10.4103/japtr.JAPTR_203_21. Epub 2021 Jul 16.
White spots are common side effects of orthodontic treatment, and their presence after debonding appears unesthetic. This study aimed to quantify and compare the visual improvement in postdebonding white spot lesions following fluoride and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) application. The sample included 42 upper premolars extracted for orthodontic reasons. Universal premolar brackets were bonded to the facial surfaces of the teeth that were exposed to a demineralization solution to create artificial white spot lesions, after which the brackets were debonded. The specimens were randomly allocated to three treatment groups ( = 14, each): acidulated phosphate fluoride (APF) gel application group; CPP-ACP paste application group; and control group. pH cycling was conducted to all groups for 14 days. Quantitative measurements were carried out using a spectrophotometer at the following times: before and after the white spot lesions artificially formed and after treating them. All groups showed significant differences in color change before and after treatment. However, there was no significant difference in the color improvement between the APF gel and CPP-ACP paste application groups. Although CPP-ACP application improved the color of the white spot lesions, it did not differ significantly from that of fluoride application.
白斑是正畸治疗常见的副作用，矫治器去除后出现的白斑影响美观。本研究旨在量化并比较应用氟化物和酪蛋白磷酸肽 - 无定形磷酸钙（CPP - ACP）后矫治器去除后白斑病变的视觉改善情况。样本包括42颗因正畸原因拔除的上颌前磨牙。将通用前磨牙托槽粘结于牙齿唇面，使其暴露于脱矿溶液中以形成人工白斑病变，之后去除托槽。将标本随机分为三个治疗组（每组n = 14）：应用含氟磷酸凝胶（APF）组；应用CPP - ACP糊剂组；对照组。对所有组进行14天的pH循环试验。在以下时间点使用分光光度计进行定量测量：人工形成白斑病变前后以及治疗后。所有组在治疗前后的颜色变化均有显著差异。然而，APF凝胶组和CPP - ACP糊剂组在颜色改善方面无显著差异。虽然应用CPP - ACP改善了白斑病变的颜色，但与应用氟化物相比无显著差异。
