Department of Anesthesiology, Cangzhou Central Hospital, No. 16 Xinhua Road, Cangzhou, Hebei, 061000, China.
J Mol Neurosci. 2022 Jan;72(1):48-55. doi: 10.1007/s12031-021-01885-9. Epub 2021 Aug 4.
Postoperative cognitive dysfunction (POCD) is a major postoperative neurological complication in children and the elderly. However, the detailed mechanisms underlying this process remain unclear. This study aims to investigate the effect of pleiotrophin on sevoflurane-induced neuroinflammation and cognitive impairment. The novel object recognition test was performed to evaluate the cognitive and motor function of aged C57BL/6 (wild-type, WT) and pleiotrophin-knockout mice treated with sevoflurane. Small molecule inhibitors targeting receptor protein tyrosine phosphatase (RPTP) β/ζ, a pleiotrophin receptor, were used to ameliorate cognitive dysfunction. Sevoflurane treatment induced cognitive dysfunction and motor impairment in aged WT mice. Sevoflurane anesthesia induced the upregulation of certain inflammatory cytokines. Pleiotrophin knockout ameliorated the sevoflurane-induced cognitive dysfunction and motor impairment in vivo. Treatment with small molecule inhibitors targeting RPTP β/ζ inhibited sevoflurane-induced neuroinflammation. In summary, pleiotrophin was shown to potentiate sevoflurane anesthesia-induced cognitive dysfunction and learning deficits in mice.
术后认知功能障碍（POCD）是儿童和老年人术后发生的一种主要的神经系统并发症。然而，其背后的详细机制尚不清楚。本研究旨在探讨多效蛋白对七氟醚诱导的神经炎症和认知障碍的影响。采用新颖物体识别试验评估了接受七氟醚治疗的老年 C57BL/6（野生型，WT）和多效蛋白敲除小鼠的认知和运动功能。针对多效蛋白受体受体蛋白酪氨酸磷酸酶（RPTP）β/ζ的小分子抑制剂用于改善认知功能障碍。七氟醚处理诱导老年 WT 小鼠认知功能障碍和运动功能障碍。七氟醚麻醉诱导某些炎症细胞因子的上调。多效蛋白敲除可改善体内七氟醚诱导的认知功能障碍和运动功能障碍。针对 RPTP β/ζ 的小分子抑制剂的治疗抑制了七氟醚诱导的神经炎症。综上所述，多效蛋白增强了七氟醚麻醉诱导的小鼠认知功能障碍和学习缺陷。
