College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.
College of Pharmacy, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-Do, 13488, Republic of Korea.
Chemosphere. 2022 Jan;286(Pt 1):131706. doi: 10.1016/j.chemosphere.2021.131706. Epub 2021 Jul 28.
Due to the use of di-isobutyl-phthalate (DiBP) in the production of soft-polyvinyl chloride articles, it is currently a hazardous substance prevalent in human daily life. However, reports on DiBP's toxicokinetics are still very scarce. And no studies have been reported on gender differences in DiBP toxicokinetics. Therefore, this study was conducted in accordance with these research needs. DiBP of 100 mg/kg has been exposed to male and female rats single or multiple times. DiBP and its major metabolite, mono-isobutyl-phthalate (MiBP), were quantified from various biological samples obtained from rats administered with DiBP. Based on these results, several toxicokinetic parameters were estimated. Toxicokinetic results between genders were compared, and from this, existence and extent of gender differences in DiBP's toxicokinetics were explored. Investigation of presence and extent of subacute toxicity in male and female rats following multiple exposures to DiBP were also conducted. This study provided comprehensive information on DiBP toxicity and gender differences that have not been reported in detail. Results of these studies imply that subacute toxicity in liver, kidney, lung, and testis of rats at 100 mg/kg of DiBP is modest and that there is little difference in toxicokinetics between genders. And in both male and female rats, the metabolism of DiBP (to MiBP) was significant, and excretion of MiBP into urine was a major indicator of DiBP exposure.
由于在软聚氯乙烯制品的生产中使用了邻苯二甲酸二异丁酯（DiBP），因此它目前是人类日常生活中普遍存在的危险物质。然而，关于 DiBP 毒代动力学的报道仍然非常稀缺。并且，没有关于 DiBP 毒代动力学性别差异的研究报告。因此，本研究根据这些研究需求进行。将 100mg/kg 的 DiBP 单次或多次暴露于雄性和雌性大鼠。从给予 DiBP 的大鼠获得的各种生物样本中定量测定 DiBP 及其主要代谢物单异丁基邻苯二甲酸酯（MiBP）。基于这些结果，估算了几个毒代动力学参数。比较了性别之间的毒代动力学结果，并从中探讨了 DiBP 毒代动力学性别差异的存在和程度。还对雄性和雌性大鼠多次接触 DiBP 后的亚急性毒性进行了调查。本研究提供了有关 DiBP 毒性和性别差异的综合信息，这些信息以前没有详细报道过。这些研究的结果表明，100mg/kg DiBP 对大鼠的肝脏、肾脏、肺和睾丸的亚急性毒性适中，性别之间的毒代动力学差异很小。并且，在雄性和雌性大鼠中，DiBP（转化为 MiBP）的代谢非常明显，MiBP 排泄到尿液中是 DiBP 暴露的主要指标。
