Dou Qian, Geng Li, Cheng Bin, Li Chao-Jun, Zeng Huiying
Institute of Marine Biomedicine, Shenzhen Polytechnic, Shenzhen 518055, China.
Chem Commun (Camb). 2021 Sep 4;57(68):8429-8432. doi: 10.1039/d1cc03496k. Epub 2021 Aug 4.
Photoinduced phosphonation of aryl triflates with trialkyl phosphites via a tandem single-electron-transfer, C-O bond cleavage and Arbuzov rearrangement process in the absence of transition-metal and external photosensitizer is reported herein. The protocol features good functional group compatibility and mild reaction conditions, providing various aryl phosphates in good to high yields. Furthermore, this strategy allows the late-stage phosphonation of complex and biologically active compounds.
本文报道了在无过渡金属和外部光敏剂的情况下，芳基三氟甲磺酸酯与亚磷酸三烷基酯通过串联单电子转移、C-O键裂解和阿尔布佐夫重排过程进行的光诱导膦酰化反应。该方法具有良好的官能团兼容性和温和的反应条件，能以良好至高收率提供各种芳基磷酸酯。此外，该策略还允许对复杂的生物活性化合物进行后期膦酰化。
