α-氯代酮的区域选择性氧/碳磷酸化：烯醇磷酸酯和β-酮基膦酸酯合成的通用方法 佩尔科夫/阿尔布佐夫反应。
Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates Perkow/Arbuzov reaction.
作者信息
Cao Yuepeng, Gao Zhenhua, Li Junchen, Bi Xiaojing, Yuan Ling, Pei Chengxin, Guo Yongbiao, Shi Enxue
机构信息
State Key Laboratory of NBC Protection for Civilian Beijing 102205 P. R. China
出版信息
RSC Adv. 2020 Aug 11;10(49):29493-29497. doi: 10.1039/d0ra05140c. eCollection 2020 Aug 5.
Abstract
A regioselective O/C phosphorylation of α-chloroketones with trialkyl phosphites was performed for the first time, which employed solvent-free Perkow reaction and NaI-assisted Arbuzov reaction under mild conditions respectively. Versatile enol phosphates were prepared in good to excellent yields as well as β-ketophosphinates.
摘要
首次实现了用亚磷酸三烷基酯对α-氯代酮进行区域选择性的O/C磷酸化反应，该反应分别在温和条件下采用无溶剂的Perkow反应和NaI辅助的Arbuzov反应。以良好至优异的产率制备了多种烯醇磷酸酯以及β-酮次膦酸酯。
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