自然杀伤细胞在杀死靶细胞时如何避免自我毁灭。
How natural killer cells avoid self-destruction when killing their targets.
机构信息
Cytoskeleton and Cancer Progression, Department of Oncology, Luxembourg Institute of Health, Luxembourg City, Luxembourg.
Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
出版信息
PLoS Biol. 2021 Aug 4;19(8):e3001339. doi: 10.1371/journal.pbio.3001339. eCollection 2021 Aug.
Abstract
How cytotoxic lymphocytes are protected against their own weapons during close combat with diseased target cells is an important and long-standing question in immunology. A study in this issue provides new insights into the mechanisms by which natural killer (NK) cells avoid self-destruction.
摘要
细胞毒性淋巴细胞在与病态靶细胞近距离交战时如何防止自身武器受到伤害，这是免疫学中长期存在的一个重要问题。本期杂志中的一项研究为自然杀伤 (NK) 细胞避免自我毁灭的机制提供了新的见解。
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