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自然杀伤细胞在杀死靶细胞时如何避免自我毁灭。

How natural killer cells avoid self-destruction when killing their targets.

机构信息

Cytoskeleton and Cancer Progression, Department of Oncology, Luxembourg Institute of Health, Luxembourg City, Luxembourg.

Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.

出版信息

PLoS Biol. 2021 Aug 4;19(8):e3001339. doi: 10.1371/journal.pbio.3001339. eCollection 2021 Aug.

DOI:10.1371/journal.pbio.3001339
PMID:34347789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8336854/
Abstract

How cytotoxic lymphocytes are protected against their own weapons during close combat with diseased target cells is an important and long-standing question in immunology. A study in this issue provides new insights into the mechanisms by which natural killer (NK) cells avoid self-destruction.

摘要

细胞毒性淋巴细胞在与病态靶细胞近距离交战时如何防止自身武器受到伤害，这是免疫学中长期存在的一个重要问题。本期杂志中的一项研究为自然杀伤 (NK) 细胞避免自我毁灭的机制提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a40/8336854/4cc73f329c1c/pbio.3001339.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a40/8336854/4cc73f329c1c/pbio.3001339.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a40/8336854/4cc73f329c1c/pbio.3001339.g001.jpg

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PLoS Biol. 2021 Aug 3;19(8):e3001328. doi: 10.1371/journal.pbio.3001328. eCollection 2021 Aug.
2
Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling.慢性淋巴细胞白血病细胞对 NK 细胞介导的裂解的固有抗性可以通过抑制 Cdc42 诱导的肌动蛋白细胞骨架重塑来克服。
Front Immunol. 2021 May 24;12:619069. doi: 10.3389/fimmu.2021.619069. eCollection 2021.
3
Lipid order and charge protect killer T cells from accidental death.
脂质有序性和电荷可保护杀伤性 T 细胞免于意外死亡。
Nat Commun. 2019 Nov 27;10(1):5396. doi: 10.1038/s41467-019-13385-x.
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Cancer Res. 2018 Oct 1;78(19):5631-5643. doi: 10.1158/0008-5472.CAN-18-0441. Epub 2018 Aug 13.
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Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse.细胞毒性免疫突触中快速且单向的穿孔素孔道输送。
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