阻塞性睡眠呼吸暂停与机动车事故风险。
Obstructive sleep apnea and risk of motor vehicle accident.
机构信息
Kaiser Permanente Washington Health Research Institute, 1730 Minor Avenue, Suite 1600, Seattle, WA, 98101, United States.
Kaiser Permanente Washington Health Research Institute, 1730 Minor Avenue, Suite 1600, Seattle, WA, 98101, United States; The CHOICE Institute, University of Washington, Department of Pharmacy, Box 357630, Seattle, WA, 98195, United States.
出版信息
Sleep Med. 2021 Sep;85:196-203. doi: 10.1016/j.sleep.2021.07.019. Epub 2021 Jul 17.
OBJECTIVE
To evaluate the association between obstructive sleep apnea (OSA) and risk of motor vehicle accident (MVA).
METHODS
We conducted a cohort study at Kaiser Permanente Washington using electronic health plan data and linked Washington State Department of Transportation MVA records. We included persons 18-79 years of age during 2005-2014. OSA was ascertained via diagnosis codes. The primary outcome, first MVA during cohort follow-up, was ascertained from state MVA records. Risk factors for MVAs, including medical conditions and medication use, were ascertained from health plan data. Multivariable Cox proportional hazards models were used to estimate the adjusted hazard ratio (HR) and 95% confidence interval (CI) for the association between OSA and study outcomes.
RESULTS
Among the 879,547 eligible persons, the unadjusted rate of MVA in those with and without OSA was 238 and 229 per 10,000 person-years, respectively. A diagnosis of OSA was associated with a 17% increased risk of MVA (adjusted HR = 1.17; 95% CI: 1.13 to 1.20).
CONCLUSION
In this large population-based study, a diagnosis of OSA was associated with a modestly increased risk of MVA.
目的
评估阻塞性睡眠呼吸暂停（OSA）与机动车事故（MVA）风险的关联。
方法
我们在 Kaiser Permanente Washington 进行了一项队列研究，使用电子健康计划数据和链接的华盛顿州交通部门 MVA 记录。我们纳入了 2005 年至 2014 年期间年龄在 18-79 岁的人群。OSA 通过诊断代码确定。主要结局指标为队列随访期间的首次 MVA，从州 MVA 记录中确定。MVA 的危险因素，包括医疗状况和药物使用，从健康计划数据中确定。多变量 Cox 比例风险模型用于估计 OSA 与研究结局之间的关联的调整后风险比（HR）和 95%置信区间（CI）。
结果
在 879,547 名合格人群中，有和没有 OSA 的 MVA 发生率分别为 238 和 229 例/10000 人年。诊断为 OSA 与 MVA 风险增加 17%相关（调整 HR = 1.17；95%CI：1.13 至 1.20）。
结论
在这项大型基于人群的研究中，OSA 的诊断与 MVA 风险的适度增加相关。
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