Single breath counting is an effective screening tool for forced vital capacity in ALS.

: To measure the correlation between single breath counting (SBC) and forced vital capacity (liters, FVC) in amyotrophic lateral sclerosis (ALS) patients and to define the utility of SBC for determining when patients meet the threshold for initiation of noninvasive positive pressure ventilation (FVC < 50% predicted [FVC]). Both patient paced (SBCpp) or externally paced (SBCep) counting along with FVC and standard clinical data were collected. Linear regression was used to examine SBCpp and SBCep as a predictor of FVC. Receiver operating characteristic curve analysis evaluated the sensitivity and specificity of SBC categorically predicting FVC of ≤50%. In 30 ALS patients, SBC explained a moderate proportion of the variance in FVC (SBCpp: = 0.431,  < 0.001; SBCep: = 0.511,  < 0.01); this proportion improved when including covariates (SBCpp: = 0.635,  < 0.01; SBCep: = 0.657,  < 0.01). Patients with minimal speech involvement performed similarly in unadjusted (SBCpp: = 0.511,  < 0.01; SBCep: = 0.595,  < 0.01) and adjusted (SBCpp: = 0.634,  < 0.01; SBCep: = 0.650,  < 0.01) models. SBCpp had 100% sensitivity and 60% specificity (area under curve (AUC) = 0.696) for predicting FVC <50%. SBCep had 100% sensitivity and 56% specificity (AUC = 0.696). With minimal speech involvement SBCpp and SBCep both had 100% sensitivity and 76.1% specificity (SPCpp: AUC = 0.845; SBCep: AUC = 0.857). SBC explains a moderate proportion of variance in FVC and is an extremely sensitive marker of poor FVC. When FVC cannot be obtained, such as during the current COVID-19 pandemic, SBC is helpful in directing patient care.