Elblová Petra, Lunova Mariia, Dejneka Alexandr, Jirsa Milan, Lunov Oleg
Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18200, Prague, Czech Republic.
Faculty of Mathematics and Physics, Charles University, Ke Karlovu 3, 121 16, Prague 2, Czech Republic.
Discov Nano. 2024 Jun 22;19(1):106. doi: 10.1186/s11671-024-04052-2.
In recent years, it has been recognized that mechanical forces play an important regulative role in living organisms and possess a direct impact on crucial cell functions, ranging from cell growth to maintenance of tissue homeostasis. Advancements in mechanobiology have revealed the profound impact of mechanical signals on diverse cellular responses that are cell type specific. Notably, numerous studies have elucidated the pivotal role of different mechanical cues as regulatory factors influencing various cellular processes, including cell spreading, locomotion, differentiation, and proliferation. Given these insights, it is unsurprising that the responses of cells regulated by physical forces are intricately linked to the modulation of nanoparticle uptake kinetics and processing. This complex interplay underscores the significance of understanding the mechanical microenvironment in shaping cellular behaviors and, consequently, influencing how cells interact with and process nanoparticles. Nevertheless, our knowledge on how localized physical forces affect the internalization and processing of nanoparticles by cells remains rather limited. A significant gap exists in the literature concerning a systematic analysis of how mechanical cues might bias the interactions between nanoparticles and cells. Hence, our aim in this review is to provide a comprehensive and critical analysis of the existing knowledge regarding the influence of mechanical cues on the complicated dynamics of cell-nanoparticle interactions. By addressing this gap, we would like to contribute to a detailed understanding of the role that mechanical forces play in shaping the complex interplay between cells and nanoparticles.
近年来，人们已经认识到机械力在生物体中发挥着重要的调节作用，并且对关键的细胞功能有着直接影响，从细胞生长到组织稳态的维持。力学生物学的进展揭示了机械信号对具有细胞类型特异性的多种细胞反应的深远影响。值得注意的是，众多研究阐明了不同机械信号作为调节因子在影响各种细胞过程中的关键作用，包括细胞铺展、运动、分化和增殖。鉴于这些见解，受物理力调节的细胞反应与纳米颗粒摄取动力学和加工的调节紧密相连也就不足为奇了。这种复杂的相互作用突显了理解机械微环境在塑造细胞行为以及进而影响细胞与纳米颗粒相互作用和加工方式方面的重要性。然而，我们对局部物理力如何影响细胞对纳米颗粒的内化和加工的了解仍然相当有限。关于机械信号如何可能影响纳米颗粒与细胞之间相互作用的系统分析，文献中存在重大空白。因此，我们这篇综述的目的是对关于机械信号对细胞 - 纳米颗粒相互作用复杂动态影响的现有知识进行全面而批判性的分析。通过填补这一空白，我们希望有助于详细了解机械力在塑造细胞与纳米颗粒之间复杂相互作用中所起的作用。
