Schwarz Patrick S, Tebcharani Laura, Heger Julian E, Müller-Buschbaum Peter, Boekhoven Job
Department of Chemistry, Technical University of Munich Lichtenbergstraße 4 85748 Garching Germany
Lehrstuhl für Funktionelle Materialien, Physik Department, Technische Universität München James-Franck-Str. 1 85748 Garching Germany.
Chem Sci. 2021 Jun 21;12(29):9969-9976. doi: 10.1039/d1sc02561a. eCollection 2021 Jul 28.
There is an increasing demand for transient materials with a predefined lifetime like self-erasing temporary electronic circuits or transient biomedical implants. Chemically fueled materials are an example of such materials; they emerge in response to chemical fuel, and autonomously decay as they deplete it. However, these materials suffer from a slow, typically first order decay profile. That means that over the course of the material's lifetime, its properties continuously change until it is fully decayed. Materials that have a sharp on-off response are self-immolative ones. These degrade rapidly after an external trigger through a self-amplifying decay mechanism. However, self-immolative materials are not autonomous; they require a trigger. We introduce here materials with the best of both, , materials based on chemically fueled emulsions that are also self-immolative. The material has a lifetime that can be predefined, after which it autonomously and rapidly degrades. We showcase the new material class with self-expiring labels and drug-delivery platforms with a controllable burst-release.
对于具有预定义寿命的瞬态材料的需求日益增长，例如自擦除临时电子电路或瞬态生物医学植入物。化学燃料驱动的材料就是这类材料的一个例子；它们在化学燃料的作用下出现，并在耗尽燃料时自动衰变。然而，这些材料存在衰变缓慢的问题，通常呈一级衰变曲线。这意味着在材料的整个寿命过程中，其性能会持续变化，直到完全衰变。具有快速开关响应的材料是自牺牲材料。这些材料在外部触发后通过自放大衰变机制迅速降解。然而，自牺牲材料不是自主的；它们需要一个触发因素。我们在此介绍兼具二者优点的材料，即基于化学燃料乳液且具有自牺牲特性的材料。这种材料具有可预定义的寿命，之后会自动且迅速地降解。我们通过自过期标签和具有可控突释功能的药物递送平台展示了这类新型材料。
